Clinicopathological Characteristics and Prognosis of Patients According to Recurrence Time After Curative Resection for Colorectal Cancer

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dc.authoridHacıbekiroğlu, İlhan/0000-0002-0333-7405
dc.authoridduran, Ayse Ocak/0000-0002-1703-726X
dc.authoriduçar, Mahmut/0000-0002-3311-6152;
dc.authorwosidÖZASLAN, ERSİN/V-3556-2017
dc.authorwosidHacıbekiroğlu, İlhan/JCN-7264-2023
dc.authorwosidduran, Ayse Ocak/ABA-7090-2021
dc.authorwosiduçar, Mahmut/KBQ-8934-2024
dc.authorwosidBerk, Veli/IXE-0017-2023
dc.contributor.authorBozkurt, Oktay
dc.contributor.authorInanc, Mevlude
dc.contributor.authorTurkmen, Esma
dc.contributor.authorKaraca, Halit
dc.contributor.authorBerk, Veli
dc.contributor.authorDuran, Ayse Ocak
dc.contributor.authorOzaslan, Ersin
dc.date.accessioned2024-06-12T11:12:44Z
dc.date.available2024-06-12T11:12:44Z
dc.date.issued2014
dc.departmentTrakya Üniversitesien_US
dc.description.abstractPurpose: To investigate clinicopathological features in patients with recurrent colorectal cancer within 1 year and more than 1 year after curative resection. Materials and Methods: We retrospectively evaluated 103 patients with disease recurrence before versus after 1 year of resection. Thirty-two patients (31%) were diagnosed with recurrence less than 1 year after curative resection for colorectal cancer (early recurrence) and 71 (69%) after more than 1 year (non-early recurrence). Results: The early recurrence group displayed a significantly lower overall survival rate for both colon cancer (p=0,01) and rectal cancer (p<0.001). Inadequate lymph node dissection was a significant predictor for early relapse. There were no statistically significant differences in clinicopathological variables such as age, sex, primary tumor localization, stage, depth of invasion, lymphovascular invasion and perineural invasion between the early and non-early recurrence groups. However, a K-ras mutation subgroup was significantly associated with early recurrence (p<0.001). Conclusions: Poor survival is associated with early recurrence for patients undergoing resection for non-metastatic colorectal cancer, as well as K-ras mutation.en_US
dc.identifier.doi10.7314/APJCP.2014.15.21.9277
dc.identifier.endpage9281en_US
dc.identifier.issn1513-7368
dc.identifier.issue21en_US
dc.identifier.pmid25422212en_US
dc.identifier.scopus2-s2.0-84918515217en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage9277en_US
dc.identifier.urihttps://doi.org/10.7314/APJCP.2014.15.21.9277
dc.identifier.urihttps://hdl.handle.net/20.500.14551/23287
dc.identifier.volume15en_US
dc.identifier.wosWOS:000351056100035en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAsian Pacific Organization Cancer Preventionen_US
dc.relation.ispartofAsian Pacific Journal Of Cancer Preventionen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPredictive And Prognostic Factorsen_US
dc.subjectEarly Recurrenceen_US
dc.subjectColorectal Canceren_US
dc.subjectK-Rasen_US
dc.subjectColon-Canceren_US
dc.subjectStage-Iien_US
dc.subjectLymphovascular Invasionen_US
dc.subject1st-Line Treatmenten_US
dc.subjectExpressionen_US
dc.subjectFluorouracilen_US
dc.subjectLeucovorinen_US
dc.subjectOxaliplatinen_US
dc.subjectPredictoren_US
dc.subjectCarcinomaen_US
dc.titleClinicopathological Characteristics and Prognosis of Patients According to Recurrence Time After Curative Resection for Colorectal Canceren_US
dc.typeArticleen_US

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