Effect of delayed radical cystectomy for invasive bladder tumors on lymph node positivity, cancer-specific survival and total survival
Küçük Resim Yok
Tarih
2018
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Sage Publicatıons Ltd.
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Introduction: Radical cystectomy (RC) is the main treatment option for patients with muscle-invasive bladder cancer (MIBC) and non-muscle-invasive bladder cancer (NMIBC), which carry the highest risk of progression. In this study, we investigated the effect of time from transurethral resection of the bladder (TUR-B) to cystectomy on lymph node positivity, cancer-specific survival and overall survival in patients with MIBC. Methods: The records were reviewed of 530 consecutive patients who had RC and pelvic lymphadenectomy procedures with curative intent performed by selected surgeons between May 2005 and April 2016. Our analysis included only patients with transitional cell carcinoma of the bladder; we excluded 23 patients with other types of tumor histology. Results: Patients who underwent delayed RC were compared with patients who were treated with early RC; both groups were similar in terms of age, gender, T stage, tumor grade, tumor differentiation, lymph node status and metastasis status. However, when both groups were compared for disease-free survival and overall survival, patients of the early-RC group had a greater advantage. Conclusions: The optimal time between the last TUR-B and RC is still controversial. A reasonable time for preoperative preparation can be allowed, but long delays, especially those exceeding 3 months, can lead to unfavorable outcomes in cancer control.
Açıklama
Kodaz, Hilmi (Trakya Author)
Anahtar Kelimeler
Cancer-Specific Survival, Disease-Free Survival, Lymph Node Positivity, Radical Cystectomy, Transitional-Cell-Carcinoma, Adjuvant Chemotherapy, Urothelial Carcinoma, Muscle Invasion, Eau Guidelines, Diagnosis, Prognosis
Kaynak
Tumori J
WoS Q Değeri
N/A
Scopus Q Değeri
N/A
Cilt
104
Sayı
6
Künye
Türk, H., Ün, S., Cinkaya, A., Kodaz, H., Parvizi, M., & Zorlu, F. (2018). Effect of delayed radical cystectomy for invasive bladder tumors on lymph node positivity, cancer-specific survival and total survival. Tumori Journal, 104(6), 434-437.
