Effect of vitamin E therapy on oxidative stress and erythrocyte osmotic fragility in patients on peritoneal dialysis and hemodialysis

Basit Öğe Kaydı
dc.authoridToprak, Omer/0000-0002-2865-1687
dc.authoridGümüştaş, Mustafa Koray/0000-0002-0745-0640
dc.authorwosidToprak, Omer/ABA-5812-2020
dc.authorwosidGümüştaş, Mustafa Koray/AAC-9427-2021
dc.contributor.authorUzum, Atilla
dc.contributor.authorToprak, Omer
dc.contributor.authorGumustas, M. Koray
dc.contributor.authorCiftci, Senturk
dc.contributor.authorSen, Saniye
dc.date.accessioned2024-06-12T11:17:12Z
dc.date.available2024-06-12T11:17:12Z
dc.date.issued2006
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBackground: Several medications have been tested with the aim of decreasing oxidative stress and erythrocyte osmotic fragility in patients on dialysis. The aim of the present study was to assess the influence of vitamin E therapy on oxidative stress and erythrocyte osmotic fragility in patients on hemodialysis (HD) and peritoneal dialysis (PD). Methods: This was a placebo-controlled study. The study was performed on 34 HD patients, 13 PD patients and 22 healthy volunteers with a mean age of 45.57 +/- 8.54 years. HD patients were divided into 2 groups: treatment (n = 19) and control (n = 15). Vitamin E was administered, 300 mg/day, to the HD treatment group and PD patients for 20 weeks. Lipid peroxidation, antioxidant condition and erythrocyte osmotic fragility (EOF) were examined before and after treatment. Results: Before the treatment, the levels of EOF (p < 0.001) and malondialdehyde (MDA) (p < 0.001) were significantly lower, and erythrocyte superoxide dismutase (SOD) (p=0.001) and vitamin E levels (p < 0.001) were significantly higher in the healthy group than PD and HD groups. Serum vitamin E increased from 0.93 +/- 0.16 to 1.09 +/- 0.14 mg/dL (p=0.001), EOF decreased from 0.49% +/- 0.03% to 0.42% +/- 0.04% NaCl (p < 0.001), and plasma MDA values decreased from 2.77 +/- 0.87 to 2.20 +/- 0.767 nmol/mL (p=0.018) in the HD treatment group after vitamin E treatment. Levels of EOF decreased from 0.51% +/- 0.09% to 0.43% +/- 0.03% NaCl in the PD treatment group after vitamin E treatment (p=0.021). Conclusion: Vitamin E therapy is effective in decreasing the levels of EOF in patients on HD and PD, and it is also effective in decreasing lipid peroxidation in patients on HD.en_US
dc.identifier.endpage745en_US
dc.identifier.issn1121-8428
dc.identifier.issn1724-6059
dc.identifier.issue6en_US
dc.identifier.pmid17173246en_US
dc.identifier.scopus2-s2.0-33947191104en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage739en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14551/24593
dc.identifier.volume19en_US
dc.identifier.wosWOS:000243730400008en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer Heidelbergen_US
dc.relation.ispartofJournal Of Nephrologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectVitamin Een_US
dc.subjectHemodialysisen_US
dc.subjectPeritoneal Dialysisen_US
dc.subjectOxidative Stressen_US
dc.subjectErythrocyte Osmotic Fragilityen_US
dc.subjectChronic-Renal-Failureen_US
dc.subjectPatients Receiving Hemodialysisen_US
dc.subjectLipid-Peroxidation Productsen_US
dc.subjectRed-Blood-Cellsen_US
dc.subjectE Supplementationen_US
dc.subjectMaintenance Hemodialysisen_US
dc.subjectSuperoxide-Dismutaseen_US
dc.subjectAntioxidant Statusen_US
dc.subjectUremic Patientsen_US
dc.subjectAnemiaen_US
dc.titleEffect of vitamin E therapy on oxidative stress and erythrocyte osmotic fragility in patients on peritoneal dialysis and hemodialysisen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu