microRNA profiling for early detection of nonmelanoma skin cancer

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dc.authoridAYAZ, LOKMAN/0000-0002-2876-055X
dc.authorwosidTamer, Lulufer/AAG-5796-2021
dc.authorwosidYildirim, Hatice/O-7121-2016
dc.authorwosidAYAZ, LOKMAN/K-6716-2013
dc.contributor.authorBalci, S.
dc.contributor.authorAyaz, L.
dc.contributor.authorGorur, A.
dc.contributor.authorYaroglu, H. Yildirim
dc.contributor.authorAkbayir, S.
dc.contributor.authorUnal, N. Dogruer
dc.contributor.authorBulut, B.
dc.date.accessioned2024-06-12T11:20:00Z
dc.date.available2024-06-12T11:20:00Z
dc.date.issued2016
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBackground. microRNAs (miRNAs) are single-stranded, noncoding RNA molecules. Given the vast regulatory potential of miRNAs and their often tissue-specific and disease-specific expression patterns, miRNAs are being assessed as possible biomarkers to aid diagnosis and prediction of different types and stages of cancers, including skin cancer. Basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) are the most common forms of nonmelanoma skin cancer (NMSC). BCC originates from the basal layer of the epidermis, while SCC arises from epidermal keratinocytes or from the dermal appendages. Although NMSCs are currently the most common types of malignancies, both BCC and SCC have a better than 95% cure rate if detected early. Aim. To identify plasma miRNAs suitable for early detection of NMSC. Methods. Expression profiles of 741 miRNAs were evaluated using high-throughput real-time quantitative PCR from plasma samples in 42 patients with NMSC and 282 healthy controls (HCs). Results. Our results demonstrated that in patients with NMSC, compared with HCs, expression levels of miR-30e-3p, miR-145-5p, miR-186-5p and miR-875-5p were significantly (P < 0.05) upregulated, while those of miR-19a-3p, miR-25-3p, miR-30a-5p, miR-451 and miR-576-3p were significantly downregulated. Conclusion. Our study suggests that the miRNAs with significant changes in expression (miR-19a-3p, miR-25-3p, miR-30a-5p, miR-145-5p and miR-186-5p) could serve as novel noninvasive biomarkers for detection of NMSC.en_US
dc.description.sponsorshipEstablishment of Molecular Substructure Laboratory for Early Diagnosis of Cancer project [TR62-09-03]; Cukurova Development Agency (Cukurova Kalkinma Ajansi, CKA), Mersin, Turkeyen_US
dc.description.sponsorshipThis study was part of the Establishment of Molecular Substructure Laboratory for Early Diagnosis of Cancer (TR62-09-03) project and was supported by grants from Cukurova Development Agency (Cukurova Kalkinma Ajansi, CKA), Mersin, Turkey.en_US
dc.identifier.doi10.1111/ced.12736
dc.identifier.endpage351en_US
dc.identifier.issn0307-6938
dc.identifier.issn1365-2230
dc.identifier.issue4en_US
dc.identifier.pmid26299703en_US
dc.identifier.scopus2-s2.0-84940056343en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage346en_US
dc.identifier.urihttps://doi.org/10.1111/ced.12736
dc.identifier.urihttps://hdl.handle.net/20.500.14551/25417
dc.identifier.volume41en_US
dc.identifier.wosWOS:000379256600002en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWiley-Blackwellen_US
dc.relation.ispartofClinical And Experimental Dermatologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectSquamous-Cell Carcinomaen_US
dc.subjectExpressionen_US
dc.subjectMelanomaen_US
dc.subjectInvasionen_US
dc.subjectHedgehogen_US
dc.subjectMir-186en_US
dc.titlemicroRNA profiling for early detection of nonmelanoma skin canceren_US
dc.typeArticleen_US

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