Nonoccupational Exposure of Agricultural Area Residents to Pesticides: Pesticide Accumulation and Evaluation of Genotoxicity

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dc.authoridhttp://orcid.org/0000-0002-1365-9897en_US
dc.contributor.authorDoganlar, Zeynep Banu
dc.contributor.authorDoganlar, Oguzhan
dc.contributor.authorTozkir, Hilmi
dc.contributor.authorGokalp, Fulya Dilek
dc.contributor.authorDogan, Ayten
dc.contributor.authorYamac, Ferah
dc.contributor.authorAskin, Orhan Onur
dc.contributor.authorAktas, Ummuhan Ersin
dc.date.accessioned2019-06-27T10:20:17Z
dc.date.available2019-06-27T10:20:17Z
dc.date.issued2018
dc.departmentFakülteler, Fen Fakültesi, Biyoloji Bölümüen_US
dc.descriptionDoganlar, Zeynep Banu (Trakya author) Doganlar, Oguzhan (Trakya author) Tozkir, Hilmi (Trakya author) Gokalp, Fulya Dilek (Trakya author) Dogan, Ayten (Trakya author) Yamac, Ferah (Trakya author)en_US
dc.description.abstractAlthough many studies related the toxic effects of pesticides on agricultural workers, little research has been done about agricultural area residents. The purpose of this work was to monitor the presence of pesticides, as well as their genotoxic and cytotoxic potential, in humans with blood samples collected from control and intensive agricultural areas in the Thrace region. Pesticide accumulations were determined by LC-MS/MS. Cytotoxicity and genotoxicity were analyzed by comet assay, and the effect of pesticide accumulation on oxidative stress, DNA repair, and molecular chaperone response were analyzed by qRT-PCR assays in the human blood samples. The agricultural area residents had a significantly higher concentration of pesticides than those in the control area at all three sampling times, and the total pesticide amounts were 4.3 and 10 times significantly higher in blood sampled in the pesticide use period (August 2015 and 2016, respectively) than in the nonuse period (November 2015). The results showed that the pesticide level in blood during the use period led to oxidative stress, DNA damage (mean comet length and % tail DNA), and unfolded/misfolded protein response. Particularly, in pesticide use season, difference between these parameters was found statistically significant with comparison to control. Our results indicate that individuals residing around a monoculture rice farming area comprise an at-risk group as a result of increased genotoxicity evidenced in human blood. We suggest that biological monitoring efforts should be used to control nonoccupational exposures to pesticides and thus safeguard the health of agricultural area residents.en_US
dc.identifier.citationDoğanlar, Z. B., Doğanlar, O., Tozkir, H., Gökalp, F. D., Doğan, A., Yamaç, F., ... & Aktaş, Ü. E. (2018). Nonoccupational Exposure of Agricultural Area Residents to Pesticides: Pesticide Accumulation and Evaluation of Genotoxicity. Archives of environmental contamination and toxicology, 75(4), 530-544.en_US
dc.identifier.doi10.1007/s00244-018-0545-7en_US
dc.identifier.endpage544en_US
dc.identifier.issue4en_US
dc.identifier.pmid30003277en_US
dc.identifier.scopus2-s2.0-85049810976en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage530en_US
dc.identifier.urihttps://doi.org/10.1007/s00244-018-0545-7
dc.identifier.urihttps://hdl.handle.net/20.500.14551/4262
dc.identifier.volume75en_US
dc.identifier.wosWOS:000446421100004en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb fo Sciencesen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofArchives of Environmental Contamination and Toxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240608_ID_Qen_US
dc.subjectGlutathione-S-Transferaseen_US
dc.subjectAntioxidant Gene-Expressionen_US
dc.subjectDna-Damageen_US
dc.subjectOxidative Stressen_US
dc.subjectPotential Biomarkeren_US
dc.subjectPrenatal Exposureen_US
dc.subjectComet Assayen_US
dc.subjectWorkersen_US
dc.subjectChlorpyrifosen_US
dc.subjectCombinationen_US
dc.titleNonoccupational Exposure of Agricultural Area Residents to Pesticides: Pesticide Accumulation and Evaluation of Genotoxicityen_US
dc.typeArticleen_US

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