Endothelial damage and hemostatic markers in patients with uncomplicated mild-to-moderate hypertension and relationship with risk factor's

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dc.contributor.authorArikan, E
dc.contributor.authorSen, S
dc.date.accessioned2024-06-12T11:17:12Z
dc.date.available2024-06-12T11:17:12Z
dc.date.issued2005
dc.departmentTrakya Üniversitesien_US
dc.description.abstractEndothelial damage, high fibrinogen levels, and platelet activity are the important accelerating factors for the development of hypertension (HT). von Willebrand factor (vWF; endothelial damage marker), fibrinogen levels, and platelet aggregability were compared between patients with uncomplicated, mild-to-moderate hypertension and healthy subjects. The relationship between traditional cardiovascular risk factors and endothelial damage and prothrombotic state was evaluated. One hundred sixty-nine (54 males, 115 females) patients with untreated and uncomplicated mild-to-moderate HT, and age, gender, and body mass index-matched 124 (58 males, 83 females) healthy subjects were enrolled in this study. Plasma vWF, fibrinogen levels, adenosine diphosphate-induced platelet aggregability, insulin, glucose, serum lipids, and uric acid were measured. Patients with HT had significantly increased fibrinogen, vWF, platelet number and aggregability induced by adenosine diphosphate, triglycerides, total/HDL-C, glucose, uric acid levels, and insulin resistance than control group. vWF and hemostatic markers were comparable between smoker and nonsmoker subjects. Platelet aggregability was positively related to systolic and diastolic blood pressure, and vWF. Fibrinogen was positively associated with body mass index (BMI), systolic and diastolic blood pressure, total cholesterol (TC), uric acid, vWF, and insulin resistance. vWF was significantly related to age, systolic blood pressure, TC, LDL-C, and total/HDL-C. Systolic blood pressure was independently related to vWF. vWF and diastolic blood pressure were significant predictors for adenosine diphosphate-induced platelet aggregability. Systolic blood pressure and vWF were independent predictors for fibrinogen levels. Uncomplicated mild-to-moderate HT had endothelial damage and is associated with a prothrombotic state. Traditional cardiovascular risk factors such as age, BMI, dyslipidemia, and insulin resistance are important contributors to the development of endothelial damage and a prothrombotic state. Therefore, it is important to control these cardiovascular risk factors along with proper treatment of HT for preventing target organ damage in mild-to-moderate HT.en_US
dc.identifier.doi10.1177/107602960501100204
dc.identifier.endpage159en_US
dc.identifier.issn1076-0296
dc.identifier.issue2en_US
dc.identifier.pmid15821821en_US
dc.identifier.scopus2-s2.0-17444364093en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage147en_US
dc.identifier.urihttps://doi.org/10.1177/107602960501100204
dc.identifier.urihttps://hdl.handle.net/20.500.14551/24600
dc.identifier.volume11en_US
dc.identifier.wosWOS:000228606200004en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWestminster Publ Incen_US
dc.relation.ispartofClinical And Applied Thrombosis-Hemostasisen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectVon Willebrand Factoren_US
dc.subjectFibrinogenen_US
dc.subjectPlatelet Aggregabilityen_US
dc.subjectHypertensionen_US
dc.subjectCardiovascular Risk Factorsen_US
dc.subjectVon-Willebrand-Factoren_US
dc.subjectSoluble P-Selectinen_US
dc.subjectFramingham Offspring Populationen_US
dc.subjectOutcomes Trial Ascoten_US
dc.subjectInsulin-Resistanceen_US
dc.subjectCardiovascular Risken_US
dc.subjectCigarette-Smokingen_US
dc.subjectPlatelet-Aggregationen_US
dc.subjectVascular-Diseaseen_US
dc.subjectBlood-Pressureen_US
dc.titleEndothelial damage and hemostatic markers in patients with uncomplicated mild-to-moderate hypertension and relationship with risk factor'sen_US
dc.typeArticleen_US

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