Subclinical Atherosclerosis in Systemic Sclerosis: Not Less Frequent Than Rheumatoid Arthritis and Not Detected With Cardiovascular Risk Indices

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dc.authoridDeniz, Rabia/0000-0003-4537-894X
dc.authoridKorkmaz, Fatma Nur Nur/0000-0002-3994-8320
dc.authoridATAGUNDUZ, PAMIR/0000-0002-6393-7461
dc.authoridOzen, Gulsen/0000-0002-5423-393X
dc.authoridAtagunduz, Pamir MP/0000-0002-6393-7461;
dc.authorwosidDeniz, Rabia/JMB-7679-2023
dc.authorwosidKorkmaz, Fatma Nur Nur/IZP-6196-2023
dc.authorwosidATAGUNDUZ, PAMIR/AAM-6944-2021
dc.authorwosidOzen, Gulsen/J-4547-2016
dc.authorwosidAtagunduz, Pamir MP/B-1615-2018
dc.authorwosidDireskeneli, Haner/AAS-5508-2020
dc.contributor.authorOzen, Gulsen
dc.contributor.authorInanc, Nevsun
dc.contributor.authorUnal, Ali U.
dc.contributor.authorKorkmaz, Fatmanur
dc.contributor.authorSunbul, Murat
dc.contributor.authorOzmen, Mustafa
dc.contributor.authorAkar, Servet
dc.date.accessioned2024-06-12T11:19:12Z
dc.date.available2024-06-12T11:19:12Z
dc.date.issued2016
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjective. To determine the frequency of subclinical atherosclerosis in patients with systemic sclerosis (SSc; scleroderma) compared to healthy subjects (HS) and rheumatoid arthritis (RA) patients and to determine the ability of cardiovascular (CV) risk indices in detecting SSc patients with subclinical atherosclerosis. Methods. A total of 110 SSc patients (102 females and 8 males, mean +/- SD age 50.5 +/- 11.9 years), 110 age-and sex-matched RA patients, and 51 HS without CV disease were examined with ultrasonography (US). Carotid intima-media thickness (cIMT) >0.90 mm and/or carotid plaques were used as the gold standard for subclinical atherosclerosis (US+). Systematic Coronary Risk Evaluation (SCORE), QRisk II, and 2013 American College of Cardiology (ACC)/American Heart Association (AHA) CV risk indices were calculated. Results. Twenty-one (19.1%) SSc patients, 24 (21.8%) RA patients, and 3 (5.9%) HS had subclinical atherosclerosis (SSc versus RA: P=0.62, SSc versus HS: P=0.029). cIMT in SSc was higher compared to HS (0.68 +/- 0.15 mm versus 0.61 +/- 0.10 mm; P=0.008) but similar to RA patients (0.66 +/- 0.14 mm; P=0.82). Subclinical atherosclerosis in SSc was associated with age (odds ratio [OR] 1.07, P=0.013), elevated erythrocyte sedimentation rate (OR 3.4, P=0.045), and pulmonary arterial hypertension (OR 4.27, P=0.012). Concerning CV risk indices, of the 21 US+ SSc patients only 0, 3 (14.2%), and 6 (28.6%) were classified as high CV risk according to SCORE, QRisk II, and ACC/AHA risk indices, respectively. Conclusion. Subclinical atherosclerosis in SSc patients is more frequent than in HS, but is as frequent as in RA patients in which accelerated atherosclerosis is clearly defined. CV risk indices for the general population are considerably insufficient to detect SSc patients with atherosclerosis.en_US
dc.identifier.doi10.1002/acr.22852
dc.identifier.endpage1546en_US
dc.identifier.issn2151-464X
dc.identifier.issn2151-4658
dc.identifier.issue10en_US
dc.identifier.pmid26866424en_US
dc.identifier.scopus2-s2.0-84988925543en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1538en_US
dc.identifier.urihttps://doi.org/10.1002/acr.22852
dc.identifier.urihttps://hdl.handle.net/20.500.14551/25106
dc.identifier.volume68en_US
dc.identifier.wosWOS:000387058400018en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofArthritis Care & Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectIntima-Media Thicknessen_US
dc.subjectCoronary-Artery Calcificationen_US
dc.subjectEndothelial Dysfunctionen_US
dc.subjectLupus-Erythematosusen_US
dc.subjectHeart-Diseaseen_US
dc.subjectScoreen_US
dc.subjectPrevalenceen_US
dc.subjectMortalityen_US
dc.subjectDeathen_US
dc.subjectInvolvementen_US
dc.titleSubclinical Atherosclerosis in Systemic Sclerosis: Not Less Frequent Than Rheumatoid Arthritis and Not Detected With Cardiovascular Risk Indicesen_US
dc.typeArticleen_US

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