Autonomic and diastolic dysfunction association with quality of life impairment in cirrhotic patients

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dc.authoridBaysal, Mehmet/0000-0001-7681-4623;
dc.authorwosidbaysal, serap/AAY-8010-2021
dc.authorwosidBaysal, Mehmet/E-9111-2018
dc.authorwosidyilmaztepe, mustafa/AGE-8367-2022
dc.contributor.authorBaysal, Mehmet
dc.contributor.authorOrtaburun, Yildiz
dc.contributor.authorSoylu, Ali Riza
dc.contributor.authorYilmaztepe, Mustafa Adem
dc.contributor.authorBaysal, Serap
dc.contributor.authorUmit, Elif
dc.contributor.authorUmit, Hasan
dc.date.accessioned2024-06-12T10:56:34Z
dc.date.available2024-06-12T10:56:34Z
dc.date.issued2020
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBackground and study aims: Cirrhosis is a multisystem disorder characterized by hyperdynamic circulation which can progress to multiple organ dysfunctions. Recent studies have demonstrated autonomic dysfunction and cirrhotic cardiomyopathy including diastolic dysfunction, systolic dysfunction with electrophysiologic abnormalities in patients with cirrhosis. Due to the long and complicated course of the disease, health related quality of life is affected. We aimed to evaluate the frequency of diastolic dysfunction and autonomic dysfunction in cirrhosis, and the effects on health-related quality of life. Patients and methods: Hundred cirrhotic patients were enrolled in the study. According to the Child-Pugh classification 35 patients were of Child A, 36 of Child B and 29 of Child C. The proportion of autonomic dysfunction was 52%, and diastolic dysfunction 51%. Autonomic dysfunction was diagnosed using bedside maneuvers and tests; diastolic dysfunction was diagnosed using the E/A ratio in echocardiographic findings. Health-related quality of life measurements was obtained from an SF-36 questionnaire. Results: Patients with advanced Child-Pugh classifications were found to have significantly lower health-related quality of life values (p < 0.05). Likewise, health-related quality of life values were observed to be significantly lower in patients with autonomic dysfunction (p < 0.05). No significant difference was found in health related quality of life measurements between patients with and without diastolic dysfunction. Conclusion: Our study showed that autonomic dysfunction and diastolic dysfunction are found in patients with cirrhosis. Further studies are needed to assess the effects of autonomic dysfunction and diastolic dysfunction on health-related quality of life. (C) 2020 Pan-Arab Association of Gastroenterology. Published by Elsevier B.V. All rights reserved.en_US
dc.identifier.doi10.1016/j.ajg.2020.01.003
dc.identifier.endpage36en_US
dc.identifier.issn1687-1979
dc.identifier.issn2090-2387
dc.identifier.issue1en_US
dc.identifier.pmid32088164en_US
dc.identifier.scopus2-s2.0-85079873181en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage32en_US
dc.identifier.urihttps://doi.org/10.1016/j.ajg.2020.01.003
dc.identifier.urihttps://hdl.handle.net/20.500.14551/19838
dc.identifier.volume21en_US
dc.identifier.wosWOS:000529355200007en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofArab Journal Of Gastroenterologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCirrhosisen_US
dc.subjectAutonomic Dysfunctionen_US
dc.subjectDiastolic Dysfunctionen_US
dc.subjectHealth-Related Quality Of Lifeen_US
dc.subjectLiveren_US
dc.subjectNeuropathyen_US
dc.subjectDiseaseen_US
dc.titleAutonomic and diastolic dysfunction association with quality of life impairment in cirrhotic patientsen_US
dc.typeArticleen_US

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