MicroRNAs EXPRESSION PROFILES IN NON-SMALL CELL LUNG CANCER

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dc.authorwosidAyaz, Lokman/K-6716-2013
dc.contributor.authorYaroglu, Hatice Yildirim
dc.contributor.authorAkbayir, Serin
dc.contributor.authorGorur, Aysegul
dc.contributor.authorBalci, Senay
dc.contributor.authorUnal, Nil
dc.contributor.authorAyaz, Lokman
dc.contributor.authorAyan, Erhan
dc.date.accessioned2024-06-12T11:08:30Z
dc.date.available2024-06-12T11:08:30Z
dc.date.issued2021
dc.departmentTrakya Üniversitesien_US
dc.description.abstractMicroRNAs (miRNAs) are a new endogenous small non-coding RNA family that arranges expression of a few genes related in normal development as well as human diseases such as cancer. miRNAs are developing as potential diagnostic and therapeutic markers with deregulated expression in various cancers including lung cancer. In this study, we aimed to find out miRNA expression profiles and to show the relationship between non-small cell lung cancer and microRNAs levels, if there is. In the present study, the expression profiles of 740 miRNA in plasma from 31 patients and 64 healthy subjects were evaluated using high-throughput real-time quantitative polymerase chain reaction. All statistical analyses were performed using the BiogazelIe's qbase PLUS 2.0 software. Our results showed that expression levels of 7 microRNAs (miR-20b-5p, -30c, -146a, -192-5p, -206, -484, -574-3p) were significantly upregulated in patients when compared to control group (p<0.05). Expression levels of five miRNAs (miR-24-3p, -30a-5p, -106b-5p, -223-3p, -331-5p) were found significantly downregulated in lung cancer patients (p<0.05). Conclusion: In conclusion, our result showed that up -regulated and down-regulated miRNAs may be important role of early detection in non-small cell lung cancer.en_US
dc.description.sponsorshipEstablishment of Molecular Substructure Laboratory for Early Diagnosis of Cancer project [TR62-09-03]; Cukurova Development Agency (Cukurova Kalkinma Ajansi, CKA), Mersin, Turkeyen_US
dc.description.sponsorshipThis study was part of the Establishment of Molecular Substructure Laboratory for Early Diagnosis of Cancer (TR62-09-03) project and was supported by grants from Cukurova Development Agency (Cukurova Kalkinma Ajansi, CKA), Mersin, Turkey.en_US
dc.identifier.endpage9113en_US
dc.identifier.issn1018-4619
dc.identifier.issn1610-2304
dc.identifier.issue7Aen_US
dc.identifier.startpage9107en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14551/22466
dc.identifier.volume30en_US
dc.identifier.wosWOS:000678352300033en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherParlar Scientific Publications (P S P)en_US
dc.relation.ispartofFresenius Environmental Bulletinen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMicrornaen_US
dc.subjectNon-Small Cell Lung Canceren_US
dc.subjectExpressionen_US
dc.subjectProfileen_US
dc.subjectDown-Regulationen_US
dc.subjectTumor-Growthen_US
dc.subjectInvasionen_US
dc.subjectCarcinomaen_US
dc.subjectGenesen_US
dc.subjectMetastasisen_US
dc.subjectGeneticsen_US
dc.subjectPromotesen_US
dc.titleMicroRNAs EXPRESSION PROFILES IN NON-SMALL CELL LUNG CANCERen_US
dc.typeArticleen_US

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