Sitagliptin and fucoidan prevent apoptosis and reducing ER stress in diabetic rat testes

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dc.authoridCerkezkayabekir, Aysegul/0000-0001-5537-1042
dc.authoridErsoy, Onur/0000-0001-9829-7903
dc.authorwosidCerkezkayabekir, Aysegul/Q-6629-2018
dc.authorwosidErsoy, Onur/AAZ-5121-2020
dc.contributor.authorKizilay, Gulnur
dc.contributor.authorErsoy, Onur
dc.contributor.authorCerkezkayabekir, Aysegul
dc.contributor.authorTopcu-Tarladacalisir, Yeter
dc.date.accessioned2024-06-12T10:59:26Z
dc.date.available2024-06-12T10:59:26Z
dc.date.issued2021
dc.departmentTrakya Üniversitesien_US
dc.description.abstractSitagliptin increases the levels of incretin hormones and stimulates a decrease in blood glucose levels, by blocking the DPP4 enzyme. We have very limited information about impact of sitagliptin on male genital system and relationship between sitagliptin/diabetes/ER. Fucoidan can be effective in blood glucose homeostasis. We goal to explain of the effect of sitagliptin and introduce an approach of fucoidan treatment in experimental diabetes in male rats. Fifty-eight Wistar albino rats were divided into C-control group and D-diabetes group: 60 mg/kg streptozotocin intraperitoneal (i.p.); DS group: STZ + 10 mg/kg sitagliptin intragastric (i.g.); DF group: STZ + 100 mg/kg fucoidan i.p.; and DSF group: STZ + 10 mg/kg sitagliptin + 100 mg/kg fucoidan. A significant decrease was detected when DS, DF and DSF groups compared to group D in blood glucose levels, basement membrane thickness and also apoptotic cell/tubule index, pJNK, caspase 3, caspase 12, GRP78, CHOP and DPP4. Sitagliptin and fucoidan have been found to be effective in blood glucose homeostasis and reducing the expression of certain proteins that lead to apoptosis and especially the proteins in the ER stress pathway. Therefore, we think that both sitagliptin and fucoidan can be effective in preventing or eliminating histopathological damages in diabetic testicular tissues, and their treatment effects can be used more.en_US
dc.description.sponsorshipTurkiye Bilimsel ve Teknolojik Arastirma Kurumu [117S452]en_US
dc.description.sponsorshipTurkiye Bilimsel ve Teknolojik Arastirma Kurumu, Grant/Award Number: 117S452en_US
dc.identifier.doi10.1111/and.13858
dc.identifier.issn0303-4569
dc.identifier.issn1439-0272
dc.identifier.issue3en_US
dc.identifier.pmid33474733en_US
dc.identifier.scopus2-s2.0-85100104158en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1111/and.13858
dc.identifier.urihttps://hdl.handle.net/20.500.14551/20447
dc.identifier.volume53en_US
dc.identifier.wosWOS:000609389500001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofAndrologiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectDiabetesen_US
dc.subjectER Stressen_US
dc.subjectFucoidanen_US
dc.subjectSitagliptinen_US
dc.subjectTestesen_US
dc.titleSitagliptin and fucoidan prevent apoptosis and reducing ER stress in diabetic rat testesen_US
dc.typeArticleen_US

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