Relationship Between Pregnancy-Associated Plasma Protein-A and Lung Cancer

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dc.authoridCoskun, Abdurrahman/0000-0002-1273-0604
dc.authoridCETINKAYA, ERDOGAN/0000-0002-0891-0020
dc.authorwosidCoskun, Abdurrahman/C-3906-2015
dc.contributor.authorBulut, Ismet
dc.contributor.authorCoskun, Abdurrahman
dc.contributor.authorCiftci, Abdullah
dc.contributor.authorCetinkaya, Erdogan
dc.contributor.authorAltiay, Gundeniz
dc.contributor.authorCaglar, Tuncay
dc.contributor.authorGulcan, Erim
dc.date.accessioned2024-06-12T11:12:03Z
dc.date.available2024-06-12T11:12:03Z
dc.date.issued2009
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBackground: Pregnancy-associated plasma protein-A (PAPP-A) has insulin-like growth factor (IGF)-dependent IGFBP-4 protease activity and plays an important role in amplifying local IGF-1 activity in wound healing, vascular repair. and bone remodeling. We postulated that PAPP-A may contribute to the availability and activity of IGFs, which affect lung cancer. Therefore, we determined the levels of PAPP-A in patients with lung cancer and their possible clinical significance. Methods: The study population consisted of 83 patients with lung cancer and 33 healthy subjects as a control group. Serum PAPP-A levels were determined using an ultrasensitive enzyme-linked immunosorbent assay. Results: The serum PAPP-A levels were higher in patients with lung cancer [median (interquartile range) 10.7 (7.6-14.2) ng/mL] than in the control group [6.2 (5.2-9.8) ng/mL, P < 0.001]. There was a significant negative correlation between the serum PAPP-A levels and Karnofsky performance status (r = -0.330; P < 0.001) and a positive correlation with patient age (r = 0.358; P < 0.001). Conclusion: PAPP-A is a proatherosclerotic metalloproteinase that is also thought to be an inflammatory marker. We found that the serum PAPP-A levels increased in patients with lung cancer and postulated that PAPP-A levels may be a prognostic factor in such cases.en_US
dc.identifier.doi10.1097/MAJ.0b013e31818967a3
dc.identifier.endpage244en_US
dc.identifier.issn0002-9629
dc.identifier.issn1538-2990
dc.identifier.issue4en_US
dc.identifier.pmid19365167en_US
dc.identifier.scopus2-s2.0-65549101107en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage241en_US
dc.identifier.urihttps://doi.org/10.1097/MAJ.0b013e31818967a3
dc.identifier.urihttps://hdl.handle.net/20.500.14551/23019
dc.identifier.volume337en_US
dc.identifier.wosWOS:000265263400004en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofAmerican Journal Of The Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPAPP-Aen_US
dc.subjectIGF-1en_US
dc.subjectIGFBP-4en_US
dc.subjectInflammationen_US
dc.subjectLung Canceren_US
dc.subjectGrowth-Factor-Ien_US
dc.subjectInflammationen_US
dc.subjectReliabilityen_US
dc.subjectExpressionen_US
dc.subjectBovineen_US
dc.subjectFetalen_US
dc.titleRelationship Between Pregnancy-Associated Plasma Protein-A and Lung Canceren_US
dc.typeArticleen_US

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