Neuroprotective effects of octreotide on diabetic neuropathy in rats

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dc.authoridEroğlu, Hüseyin Avni/0000-0002-1040-3255
dc.authoridsolmaz, volkan/0000-0002-9045-2347
dc.authoridErbas, Oytun/0000-0001-5427-8428
dc.authoridTaskiran, Dilek/0000-0002-4505-0939
dc.authorwosidCinar, Bilge Piri/AAA-5038-2021
dc.authorwosidERBAS, OYTUN/ABA-7380-2021
dc.authorwosidEroğlu, Hüseyin Avni/ABF-4291-2021
dc.authorwosidTaskiran, Dilek/AAD-1790-2020
dc.contributor.authorSolmaz, Volkan
dc.contributor.authorCinar, Bilge Piri
dc.contributor.authorYigitturk, Gurkan
dc.contributor.authorOzlece, Hatice Kose
dc.contributor.authorEroglu, Huseyin Avni
dc.contributor.authorTekatas, Aslan
dc.contributor.authorErbas, Oytun
dc.date.accessioned2024-06-12T10:59:24Z
dc.date.available2024-06-12T10:59:24Z
dc.date.issued2017
dc.departmentTrakya Üniversitesien_US
dc.description.abstractThe purpose of the present study is to investigate the possible healing effects of octreotide (OCT) on motor performance, electrophysiological and histopathological findings of diabetic neuropathy in a rat model of diabetes mellitus (DM). To induce diabetes, rats were administered a single dose (60 mg/kg) of streptozotocin (STZ). Diabetic rats were treated either with saline (1 ml/kg/day, n = 7) or OCT (0.1 mg/kg/ day, n = 7) for four weeks. Seven rats served as control group and received no treatment. At the end of the study, electromyography (EMG), gross motor function (inclined plate test), general histology and the perineural thickness of sciatic nerve were evaluated. At the end of study, weight loss was significantly lower in OCT treated rats than that of saline treated ones (p < 0.001). Electrophysiologically, compound muscle action potential (CMAP) amplitudes of the saline treated DM group were significantly reduced than those of controls (p < 0.0001). Also, distal latency and CMAP durations were significantly prolonged in saline treated DM group (p < 0.05) compared to control. However, treatment of diabetic rats with OCT significantly counteracted these alterations in EMG. Furthermore, OCT significantly improved the motor performance scores in diabetic rats (p < 0.05). Histomorphometric assessment of the sciatic nerve demonstrated a significant reduction in perineural thickness in OCT treated group compared to saline group. In conclusion, OCT possesses beneficial effects against STZ-induced diabetic neuropathy, which promisingly support the use of OCT as a neuroprotective agent in patients with diabetic neuropathy. (C) 2017 Elsevier Masson SAS. All rights reserved.en_US
dc.identifier.doi10.1016/j.biopha.2017.02.027
dc.identifier.endpage472en_US
dc.identifier.issn0753-3322
dc.identifier.issn1950-6007
dc.identifier.pmid28249248en_US
dc.identifier.scopus2-s2.0-85013964894en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage468en_US
dc.identifier.urihttps://doi.org/10.1016/j.biopha.2017.02.027
dc.identifier.urihttps://hdl.handle.net/20.500.14551/20434
dc.identifier.volume89en_US
dc.identifier.wosWOS:000402468200054en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier France-Editions Scientifiques Medicales Elsevieren_US
dc.relation.ispartofBiomedicine & Pharmacotherapyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDiabetes Mellitusen_US
dc.subjectDiabetic Neuropathyen_US
dc.subjectOctreotideen_US
dc.subjectElectromyographyen_US
dc.subjectSevere Acute-Pancreatitisen_US
dc.subjectNerveen_US
dc.subjectLevetiracetamen_US
dc.subjectBaicalinen_US
dc.titleNeuroprotective effects of octreotide on diabetic neuropathy in ratsen_US
dc.typeArticleen_US

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