Transient changes in inflammatory and oxidative stress markers with total sleep deprivation

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dc.authoridGorgulu, Yasemin/0000-0002-3401-4879
dc.authorid, Rugül/0000-0003-2596-0473
dc.authoridCaliyurt, Okan/0000-0002-0513-0619
dc.authorwosidçınar, rugül köse/S-8927-2019
dc.authorwosidGorgulu, Yasemin/S-4355-2017
dc.authorwosidCaliyurt, Okan/ABE-7339-2020
dc.authorwosid, Rugül/AAI-1711-2019
dc.contributor.authorCinar, Rugul Kose
dc.contributor.authorGorgulu, Yasemin
dc.contributor.authorCaliyurt, Okan
dc.contributor.authorSonmez, Bulent
dc.date.accessioned2024-06-12T11:14:13Z
dc.date.available2024-06-12T11:14:13Z
dc.date.issued2016
dc.departmentTrakya Üniversitesien_US
dc.description.abstractSleep deprivation (SD) is known to modulate inflammatory and oxidative stress markers. How these markers change over the SD period have seldom been studied in healthy young adults. Seventeen healthy young adults with a mean age of 19.8 +/- 1.0 years underwent an experimental protocol consisting of 36 h of total SD. We tested whether the stress response was towards adaptation or a worsening of the response. We analysed blood for gene expression levels of interleukins (IL-1 beta, IL-6, IL-33), tumour necrosis factor-alpha (TNF-alpha), glutathione (GSH), heat-shock protein 70 (HSP70), and a member of the signal transducers and activators of transcription (STAT3) family with quantitative real-time polymerase chain reaction (qRT-PCR). We also measured plasma levels of cortisol and malondialdehyde (MDA) with a spectrophotometer. All measurements were made at baseline and at the 24th and 36th hour of the study. IL-1 beta, IL-6, and GSH gene expression levels were up-regulated at the 24th hour and down-regulated at the 36th hour (p < 0.05 for all). IL-33 gene expression levels showed no change at the 24th hour and down-regulation at the 36th hour. TNF-alpha gene expression levels were down-regulated at the 24th hour and up-regulated at the 36th hour. Cortisol levels showed a gradual increase at all the measurement points (p < 0.05 for all). HSP70, MDA, and STAT3 had no significant changes. The present study demonstrated that the hyperactivation of the hypothalamic-pituitary-adrenal (HPA) and sympathetic-adrenal-medullary (SAM) axes shown by the up-regulation of genes seen after a sleepless night is a normal response to acute stress, and by increasing the time spent sleepless, the HPA and SAM axes may return to their normal functioning levels.en_US
dc.description.sponsorshipTrakya University Scientific Research Project Committee (TUBAP)en_US
dc.description.sponsorshipThe Trakya University Scientific Research Project Committee (TUBAP) provided financial support for the conduct of the research. This committee evaluates the researches and provides financial support for the ones that they see relevant for the scientific improvement of the university. The Technology Research and Development Center of Trakya University (TUTAGEM) participated in the laboratory process. TUTAGEM is one of the laboratories of the university.en_US
dc.identifier.doi10.1007/s41105-016-0071-9
dc.identifier.endpage396en_US
dc.identifier.issn1446-9235
dc.identifier.issn1479-8425
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-84988893638en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage387en_US
dc.identifier.urihttps://doi.org/10.1007/s41105-016-0071-9
dc.identifier.urihttps://hdl.handle.net/20.500.14551/23851
dc.identifier.volume14en_US
dc.identifier.wosWOS:000384980200009en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSpringer Japan Kken_US
dc.relation.ispartofSleep And Biological Rhythmsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectSleep Deprivationen_US
dc.subjectInflammatory Cytokinesen_US
dc.subjectOxidative Stress Markersen_US
dc.subjectThe Signal Transducers And Activators Of The Transcription Familyen_US
dc.subjectMetabolic Consequencesen_US
dc.subjectCircadian Disruptionen_US
dc.subjectSignal Transduceren_US
dc.subjectCortisolen_US
dc.subjectDurationen_US
dc.subjectHealthen_US
dc.subjectMechanismsen_US
dc.subjectExpressionen_US
dc.subjectAllostasisen_US
dc.subjectCytokinesen_US
dc.titleTransient changes in inflammatory and oxidative stress markers with total sleep deprivationen_US
dc.typeArticleen_US

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