Effect of clinical and pathological features of gastrointestinal stromal tumors on overall survival and prognosis: Single center experience
Küçük Resim Yok
Tarih
2019
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Aim: Gastrointestinal stromal tumors (GIST) are the most common mesenchymal tumors of thegastrointestinal tract. We aimed to evaluate the clinicopathological features of the patients in Thrace andimprove our management.Material and Method: In this retrospective study, 68 patients with a diagnosis of GIST referred to TrakyaUniversity Medical School Hospital between 1997 and 2015 were evaluated.Results: The most common symptom was abdominal pain (38.2%) and the location was small-intestine(42.6%). Large masses had higher metastasis and relapse rate. The mean tumor size with relapse was11.8 ± 3.8 cm meanwhile it was 6.5 ± 3.0 cm in non-relapsed patients (p ¼ 0.01). The mean size of thetumor was 13.5 ± 4.4 in the metastatic group although this data was 8.8 ± 4.7 cm in the non-metastaticgroup (p ¼ 0.01). With necrotic tumors, mitotic rate and size were higher. The mean mitosis count was21.0 ± 3.6 in necrotic tumors and 7.2 ± 9.9 in non-necrotic tumors (p ¼ 0.005). The mean size was10.8 ± 5.0 cm in necrotic tumors and 5.6 ± 3.0 cm in non-necrotic tumors (p ¼ 0.009). According to AFIPcriteria, most of the patients were in the high-risk group (57.4%). Overall survival (OS) was longer in nonsmokers and non-drinkers. Median OS was 80.16 months in non-smoker group (95% CI, 27.83e132.49)and 24.64 months (95% CI, 15.49e33.78) in the smoker group (p ¼ 0.001). The median OS was 80.09months in the non-drinker group (95% CI, 13.99e146.20) and 24.64 months (95% CI, 13.18e36.10) indrinker group (p ¼ 0.05). Median OS in stomach GIST was 41.39 months, in small-intestine were 80.09months and in the colon were 35.68 months (p ¼ 0.032). Patients underwent surgery had longer overallsurvival. Median OS was 80.09 months in patients undergone surgery and 16.98 months in patients hadnot been operated (p ¼ 0.001). Overall survival was longer in GIST with mitotic rate <5/50HPF than with>5/50HPF. Median OS was 80.16 months in patients who had less than 5 mitosis and 39.22 months inhigher mitotic rate (95% CI, 31.58e46.87) (p ¼ 0.034). Overall survival was shorter in GIST with Ki-67 > 5%than with 5%>. Median OS was 80.16 months (95% CI, 28.80e49.65) in <5% and 39.22 months (95% CI,28.80e49.65) in 5% $leq$ Ki-67 (p ¼ 0.004).Conclusions: The most important factors about the survival and prognosis of GIST are location, size,mitotic rate, Ki-67, necrosis and surgery status. Using tobacco/alcohol may be related to survival. Thisstudy should be further investigated with extensive data.
Açıklama
Anahtar Kelimeler
Kaynak
Journal of oncological sciences
WoS Q Değeri
Scopus Q Değeri
Cilt
5
Sayı
3
