Bronchiectasis in Türkiye: Data from a Multicenter Registry (Turkish Adult Bronchiectasis Database)

Basit Öğe Kaydı
dc.authoridBAYDAR TOPRAK, OYA/0000-0001-7320-976X
dc.authorwosidBAYDAR TOPRAK, OYA/U-9880-2018
dc.contributor.authorEdis, Ebru Cakir
dc.contributor.authorCilli, Aykut
dc.contributor.authorKizilirmak, Deniz
dc.contributor.authorCoskun, Ayson Sakar
dc.contributor.authorGuler, Nurcan
dc.contributor.authorCicek, Sedat
dc.contributor.authorSevinc, Can
dc.date.accessioned2024-06-12T11:18:40Z
dc.date.available2024-06-12T11:18:40Z
dc.date.issued2024
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBackground: Bronchiectasis is a chronic lung disease characterized by permanent bronchial wall dilatation. Although it has been known as an orphan disease, it has recently gained attention because of registry -based studies and drug research. Aims: We aimed to use a multicenter database to analyze and compare data regarding the etiology, associated comorbidities, microbiological characteristics, and preventive strategies of bronchiectasis in T & uuml;rkiye to those of other countries. Study Design: A multicenter prospective cohort study. Methods: The multicenter, prospective cohort study was conducted between March 2019 and January 2022 using the Turkish Adult Bronchiectasis Database, in which 25 centers in T & uuml;rkiye participated. Patients aged > 18 years who presented with respiratory symptoms such as cough, sputum, and dyspnea and were diagnosed with non -cystic fibrosis bronchiectasis using computed tomography were included in the study. Demographic information, etiologies, comorbidities, pulmonary functions, and microbiological, radiological, and clinical data were collected from the patients. Results: Of the 1,035 study participants, 518 (50%) were females. The mean age of the patients was 56.1 +/- 16.1 years. The underlying etiology was detected in 565 (54.6%) patients. While postinfectious origin was the most common cause of bronchiectasis (39.5%), tuberculosis was identified in 11.3% of the patients. An additional comorbidity was detected in 688 (66.5%) patients. The most common comorbidity was cardiovascular disease, and chronic obstructive pulmonary disease (COPD) and bronchiectasis was identified in 19.5% of the patients. The most commonly detected microbiological agent was Pseudomonas aeruginosa (29.4%). Inhaled corticosteroids (ICS) were used in 70.1% of the patients, and the frequency of exacerbations in the last year was significantly higher in patients using ICS than in nonusers (p < 0.0001). Age [odds ratio (OR): 1.028; 95% confidence interval (CI): 1.005-1.051], cachexia (OR: 4.774; 95% CI: 2,054-11,097), high modified medical research council dyspnea scale score (OR: 1,952; 95% CI: 1,459-2,611), presence of chronic renal failure (OR: 4,172; 95% CI: 1,249-13,938) and use of inhaled steroids (OR: 2,587; 95% CI: 1,098-6,098) were significant risk factors for mortality. Mortality rates were higher in patients with COPD than in those with no COPD (21.7-9.1%, p = 0.016). Patients with bronchiectasis and COPD exhibited more frequent exacerbations, exacerbation -related hospitalizations, and hospitalization in the intensive care unit in the previous year than patients without COPD. Conclusion: This is the first multicenter study of bronchiectasis in T & uuml;rkiye. The study results will provide important data that can guide the development of health policies in T & uuml;rkiye on issues such as infection control, vaccination, and the unnecessary use of antibiotics and steroids.en_US
dc.identifier.doi10.4274/balkanmedj.galenos.2024.2023-12-57
dc.identifier.endpage212en_US
dc.identifier.issn2146-3123
dc.identifier.issn2146-3131
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-85192039378en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage206en_US
dc.identifier.urihttps://doi.org/10.4274/balkanmedj.galenos.2024.2023-12-57
dc.identifier.urihttps://hdl.handle.net/20.500.14551/24913
dc.identifier.volume41en_US
dc.identifier.wosWOS:001215913000006en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherGalenos Publ Houseen_US
dc.relation.ispartofBalkan Medical Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCystic Fibrosis Bronchiectasisen_US
dc.subjectThoracic Societyen_US
dc.subjectEtiologyen_US
dc.subjectExacerbationsen_US
dc.subjectMortalityen_US
dc.subjectSurvivalen_US
dc.subjectDiseaseen_US
dc.subjectRisken_US
dc.titleBronchiectasis in Türkiye: Data from a Multicenter Registry (Turkish Adult Bronchiectasis Database)en_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu