99mTc-dextran scintigraphy to detect disease activity in patients with rheumatoid arthritis

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dc.authoridTuna, Filiz/0000-0002-9563-8028
dc.authoridtuna, hakan/0000-0002-5980-8413
dc.authorwosidtuna, filiz/ABD-4110-2020
dc.contributor.authorKaya, M
dc.contributor.authorTuna, H
dc.contributor.authorFirat, MF
dc.contributor.authorTuna, F
dc.contributor.authorSeren, G
dc.contributor.authorYigitbasi, ÖN
dc.date.accessioned2024-06-12T10:59:39Z
dc.date.available2024-06-12T10:59:39Z
dc.date.issued2004
dc.departmentTrakya Üniversitesien_US
dc.description.abstractAim To test the applicability of Tc-99m-dextran joint scintigraphy in the assessment of disease activity in patients with rheumatoid arthritis (RA), and to compare it with the clinical disease activity scores and laboratory parameters. Methods Twenty-seven patients with RA were investigated using Tc-99m-dextran joint scintigraphy. The images were evaluated semi-quantitatively and the regional uptakes of the radiopharmaceutical were calculated for the knee, wrist and ankle joints. The clinical and laboratory parameters were collected and fully analysed. An articular Ritchie index (a tender joint score), the number of swollen joints (Sw), the number of tender joints, the morning stiffness h, the total Ritchie articular index (R), the visual analogue scale (VAS) and the Disease Activity Score (DAS) were determined for all patients. Results Compared with controls, patients with RA had significantly higher regional Tc-99m-dextran uptake in the knee, wrist and ankle joints (P=0.001). The regional 99mTc-dextran uptake showed no correlation with the patient's age, gender, duration of disease, number of swollen joints (Sw), number of tender joints, morning stiffness (h), VAS, total Ritchie articular index and DAS, or any laboratory parameters. There was a significant correlation between the regional Tc-99m-dextran uptake for individual joints and the articular Ritchie index of the right and left wrist (r=0.42, P=0.03; r=0.45, P=0.02), right and left knee (r=0.66, P<0.0001; r=0.80, P<0.0001) and right and left ankle (r=0.47, P=0.014; r=0.76, P<0.0001), respectively. Conclusions This study demonstrates that 99mTc-dextran scintigraphy is a sensitive method to detect active joint inflammation and could be useful in the management of patients with RA. (C) 2004 Lippincott Williams Wilkins.en_US
dc.identifier.doi10.1097/01.mnm.0000126632.32413.2e
dc.identifier.endpage601en_US
dc.identifier.issn0143-3636
dc.identifier.issn1473-5628
dc.identifier.issue6en_US
dc.identifier.pmid15167520en_US
dc.identifier.startpage597en_US
dc.identifier.urihttps://doi.org/10.1097/01.mnm.0000126632.32413.2e
dc.identifier.urihttps://hdl.handle.net/20.500.14551/20527
dc.identifier.volume25en_US
dc.identifier.wosWOS:000222089900011en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofNuclear Medicine Communicationsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDisease Activityen_US
dc.subjectRheumatoid Arthritisen_US
dc.subjectTc-99m-Dextran Scintigraphyen_US
dc.subjectHuman-Immunoglobulin-Gen_US
dc.subjectTc-99m Dextranen_US
dc.subjectInflammationen_US
dc.subjectTc-99(M)-Higen_US
dc.subjectLeukocytesen_US
dc.subjectInjectionen_US
dc.title99mTc-dextran scintigraphy to detect disease activity in patients with rheumatoid arthritisen_US
dc.typeArticleen_US

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