The Role of Serum Cytokines in the Pathogenesis of Hepatic Osteodystrophy in Male Cirrhotic Patients

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dc.authoridTezel, Ahmet/0000-0002-3054-475X
dc.authoridUmit, Hasan/0000-0002-3651-4180
dc.authorwosidUmit, Hasan/T-6236-2019
dc.authorwosidKöker, Ibrahim Hakkı/AAO-8538-2021
dc.contributor.authorSoylu, Ali Riza
dc.contributor.authorTuglu, Cengiz
dc.contributor.authorArikan, Ender
dc.contributor.authorYetisyigit, Tarkan
dc.contributor.authorKunduracilar, Hakan
dc.contributor.authorKoker, Ibrahim Hakki
dc.contributor.authorUnsal, Gulbin
dc.date.accessioned2024-06-12T11:20:07Z
dc.date.available2024-06-12T11:20:07Z
dc.date.issued2012
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjective. In this study, we aimed to investigate the possible role of serum cytokines in the development of hepatic osteodystrophy. Matherial and Methods. 44 consecutive male cirrhotic patients (17 alcoholic, 20 hepatitis B, 7 hepatitis C), 15 age- and sex-matched chronic alcoholics without liver disease, and 17 age- and sex-matched healthy controls were included in the study during one year period. Bone mineral density was measured by dual X-ray absorptiometry in the lumbar vertebrate and femoral neck. Serum interleukin levels were measured by ELISA method. Results. Although osteopenia frequency between our cirrhotic patients was 20%, there was no difference in T-scores among the controls and other groups. Serum interleukin-1, interleukin-8, and tumor necrosis factor-alpha levels were not different between all groups. Serum interleukin-2 and interleukin-6 levels were higher in the cirrhotics than controls (P < 0.001). However, there were no significant difference between osteopenic and nonosteopenic cirrhotics. Conclusion. According to the results of the study in this small population of 44 male cirrhotic patients, frequency of hepatic osteopenia is small and serum interleukins 1, 2, 6, 8, and tumor necrosis factor-alpha may not play a role in the pathogenesis of hepatic osteodystrophy. Further studies in which large number of patients involved are necessary in this field.en_US
dc.identifier.doi10.1155/2012/425079
dc.identifier.issn1687-6121
dc.identifier.issn1687-630X
dc.identifier.pmid23097664en_US
dc.identifier.scopus2-s2.0-84869046068en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.urihttps://doi.org/10.1155/2012/425079
dc.identifier.urihttps://hdl.handle.net/20.500.14551/25475
dc.identifier.volume2012en_US
dc.identifier.wosWOS:000310014200001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherHindawi Ltden_US
dc.relation.ispartofGastroenterology Research And Practiceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectTumor-Necrosis-Factoren_US
dc.subjectBone-Resorptionen_US
dc.subjectMineral Metabolismen_US
dc.subjectFactor-Alphaen_US
dc.subjectOsteoporosisen_US
dc.subjectInterleukin-1en_US
dc.subjectHistomorphometryen_US
dc.subjectTurnoveren_US
dc.subjectDensityen_US
dc.subjectDiseaseen_US
dc.titleThe Role of Serum Cytokines in the Pathogenesis of Hepatic Osteodystrophy in Male Cirrhotic Patientsen_US
dc.typeArticleen_US

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