The importance of aprotinin and pentoxifylline in preventing leukocyte sequestration and lung injury caused by protamine at the end of cardiopulmonary bypass surgery

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dc.authoridSunar, Hasan/0000-0002-1276-8549
dc.authoridYuksel, Volkan/0000-0001-9518-2588
dc.authoridCIKIRIKCIOGLU, MUSTAFA/0000-0003-1143-347X
dc.authorwosidSunar, Hasan/A-8685-2018
dc.contributor.authorEge, T
dc.contributor.authorArar, C
dc.contributor.authorCanbaz, S
dc.contributor.authorCikirikcioglu, M
dc.contributor.authorSunar, H
dc.contributor.authorYuksel, V
dc.contributor.authorDuran, E
dc.date.accessioned2024-06-12T10:55:45Z
dc.date.available2024-06-12T10:55:45Z
dc.date.issued2004
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBackground: Protamine has adverse effects on pulmonary gas exchange during the postoperative period. The objective of this study was to investigate the importance of aprotinin and pentoxifylline in preventing the leukocyte sequestration and lung injury caused by protamine administered after the termination of cardiopulmonary bypass (CPB). Methods: Participants (n = 39) were allocated into three groups at the termination of CPB: Group 1, (control group, n = 16); Group 2 (aprotinin group, n = 12), who received protamine + aprotinin (15 000 IU/kg); and Group 3 (Pentoxifylline group, n = 11), who received protamine + pentoxifylline (10 mg/kg). Leukocyte counts in pulmonary and radial arteries were determined after the termination of CPB and before any drug was given (t(1)), and 5 minutes (t(2)), 2 hours (t(3)), 6 hours (t(4)) and 12 hours (t(s)) after the administration of protamine. Alveolar-arterial O-2 gradient (A-aO(2)) and dynamic pulmonary compliance were measured at t(1), t(2) and t(3). Results: In the control group, an increase in pulmonary leukocyte sequestration was observed 5 minutes and 2 hours after protamine administration, after which this difference disappeared. No significant degree of pulmonary sequestration was detected in any measurements after protamine was administered in the aprotinin and pentoxifylline (PTX) groups. Dynamic lung compliance was 50.1, 45.2 and 47.2 ml/cm H2O in the control group, 49.2, 61.1 and 56.3 ml/ cm H2O in the aprotinin group, and 49.5, 54.5 and 50.4 ml/cm H2O in the PTX group. The A-aO(2) gradient was 212.2, 263.3 and 254.3 mmHg in the control group, 209.4, 257.1 and 217.3 mmHg in the aprotinin group, and 211.3, 260.8 and 219.2 mmHg in the PTX group. Conclusion: Aprotinin and PTX treatments have favourable effects on lung function by reducing protamine-induced leukocyte sequestration into lungs at the end of CPB.en_US
dc.identifier.doi10.1055/s-2004-815798
dc.identifier.endpage15en_US
dc.identifier.issn0171-6425
dc.identifier.issue1en_US
dc.identifier.pmid15002070en_US
dc.identifier.scopus2-s2.0-1542619618en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage10en_US
dc.identifier.urihttps://doi.org/10.1055/s-2004-815798
dc.identifier.urihttps://hdl.handle.net/20.500.14551/19544
dc.identifier.volume52en_US
dc.identifier.wosWOS:000220248200003en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherGeorg Thieme Verlag Kgen_US
dc.relation.ispartofThoracic And Cardiovascular Surgeonen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCardiopulmonary Bypassen_US
dc.subjectProtamineen_US
dc.subjectAprotininen_US
dc.subjectPentoxifyllineen_US
dc.subjectAlveolar-Arterial O-2 Gradienten_US
dc.subjectDynamic Complianceen_US
dc.subjectCardiac-Surgeryen_US
dc.subjectPulmonary-Hypertensionen_US
dc.subjectDysfunctionen_US
dc.subjectReperfusionen_US
dc.subjectOperationen_US
dc.subjectDamageen_US
dc.titleThe importance of aprotinin and pentoxifylline in preventing leukocyte sequestration and lung injury caused by protamine at the end of cardiopulmonary bypass surgeryen_US
dc.typeArticleen_US

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