LACK OF EVIDENCE FOR CONTRIBUTION OF ENDOTHELIAL NITRIC OXIDE SYNTHASE INTRON 4 VNTR GENE POLYMORPHISMS TO DEVELOPMENT OF ISCHEMIC STROKE IN TURKISH SUBJECTS

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dc.authoridPalabıyık, Orkide/0000-0002-3488-3740
dc.authorwosidPalabıyık, Orkide/Q-2792-2019
dc.contributor.authorSipahi, T.
dc.contributor.authorBasak, A. A.
dc.contributor.authorOzgen, Z.
dc.contributor.authorAksoy, A.
dc.contributor.authorOmurlu, I. K.
dc.contributor.authorPalabiyik, O.
dc.contributor.authorCakina, S.
dc.date.accessioned2024-06-12T11:00:25Z
dc.date.available2024-06-12T11:00:25Z
dc.date.issued2009
dc.departmentTrakya Üniversitesien_US
dc.description.abstractThe gene polymorphisms of the vasodilator endothelial nitric oxide synthase (eNOS) are considered as important candidate genetic risk factors for vascular diseases. The present study aimed to assess the genotypic distribution and the allelic frequency of the four repeals (a allele), and the five repeats (b allele) of 27 bp in intron 4 of eNOS gene (eNOS VNTR 4 a/b) in Turkish ischemic stroke patients compared to controls. The study population included 197 (102 males, 95 females) patients with ischemic stroke which were categorized according to the Trial of ORG 10172 in Acute Stroke Treatment (TOAST) as large vessel disease or small vessel disease patients, and 144 (36 males, 108 females) controls. The eNOS VNTR 4 a/b gene polymorphisms were identified with a polymerase chain reaction. Genotypes were defined as aa; 394 bp fragment, ab; 394 and 421 bp fragments, and bb; 421 bp fragment according to the presence of the a and b alleles. In this stroke-control study, we did not find any significant difference in either the genotypic distribution or allelic frequency of eNOS VNTR 4 a/b gene polymorphism between the ischemic stroke patients and the controls (p>0.05). We also did not find any significant difference in either the genotypic distribution or allelic frequency according to gender (p>0.05). In addition, there was also no significant difference for the genotype distribution and the allelic frequency among the stroke subtypes (p>0.05), or according to gender in stroke subgroups (p>0.05). The results suggested the lack of an association between the VNTR 4 a/b gene polymorphisms of eNOS gene and ischemic stroke or between the VNTR 4 a/b gene polymorphisms of eNOS gene and subtypes of ischemic stroke in Turkish population in the Trakya region.en_US
dc.identifier.doi10.1080/13102818.2009.10817673
dc.identifier.endpage1377en_US
dc.identifier.issn1310-2818
dc.identifier.issn1314-3530
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-70349632973en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1372en_US
dc.identifier.urihttps://doi.org/10.1080/13102818.2009.10817673
dc.identifier.urihttps://hdl.handle.net/20.500.14551/20819
dc.identifier.volume23en_US
dc.identifier.wosWOS:000269202400020en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofBiotechnology & Biotechnological Equipmenten_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectEndothelial Nitric Oxide Synthaseen_US
dc.subjectIschemic Strokeen_US
dc.subjectEnos VNTRen_US
dc.subject4 A/B Gene Polymorphismen_US
dc.subjectAngiotensin-Converting Enzymeen_US
dc.subjectGlu/Asp Polymorphismen_US
dc.subjectNo Associationen_US
dc.subjectRisken_US
dc.subjectDiseaseen_US
dc.subjectHypertensionen_US
dc.subjectVariantsen_US
dc.titleLACK OF EVIDENCE FOR CONTRIBUTION OF ENDOTHELIAL NITRIC OXIDE SYNTHASE INTRON 4 VNTR GENE POLYMORPHISMS TO DEVELOPMENT OF ISCHEMIC STROKE IN TURKISH SUBJECTSen_US
dc.typeArticleen_US

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