Electrolyte Free Water Clearance Could Be an Early Sign of Renal Dysfunction in Renal Transplant Patients

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dc.authoridSeyahi, Nurhan/0000-0001-7427-618X
dc.authoridAltiparmak, Mehmet Riza/0000-0002-3579-1100
dc.authorwosidSeyahi, Nurhan/AAB-3792-2020
dc.authorwosidAltiparmak, Mehmet Riza/AAC-2508-2021
dc.contributor.authorTekgunduz, E.
dc.contributor.authorApaydin, S.
dc.contributor.authorSeyahi, N.
dc.contributor.authorAltiparmak, M. R.
dc.date.accessioned2024-06-12T11:17:50Z
dc.date.available2024-06-12T11:17:50Z
dc.date.issued2009
dc.departmentTrakya Üniversitesien_US
dc.description.abstractData on free water excretion capacity of renal transplant recipients are scant. The aim of this study was to evaluate the ability of electrolyte free water clearance (E-CH2O) by the allograft in renal transplant patients and the effects of various immunosuppressive drugs. Renal transplant recipients with good graft function (creatinine < 1.5 mg/dL) as well as controls were divided into five groups according to their immunosuppressive regimen: group 1, azathioprine (n = 1.5); group II, cyclosporine (n = 28); group III, tacrolimus (n = 28); group IV healthy controls (n = 20); and group V renal transplant donors (n = 16). Following a 12-hour fast, we administered oral water loading (20 mL/kg) with urine collection for 3 hours. We calculated creatinine clearance for 3 hours and E-CH2O. No matter which immunosuppressive drug, the E-CH2O of recipients (groups I, II, and III) was lower than that of donors or healthy controls. The creatinine clearance of the cyclosporine arm was significantly lower than all of the other groups. Decreased E-CH2O in renal transplant patients might be due to diminished water input to the loop of Henle related to subclinical allograft insufficiency as a result of posttransplantation pathology and/or immunosuppressive drug therapy or the transport of water into the extrarenal interstitium as a result of vascular endothelial dysfunction due to the pretransplant uremic milleu.en_US
dc.identifier.doi10.1016/j.transproceed.2009.06.224
dc.identifier.endpage3730en_US
dc.identifier.issn0041-1345
dc.identifier.issn1873-2623
dc.identifier.issue9en_US
dc.identifier.pmid19917375en_US
dc.identifier.scopus2-s2.0-71749099386en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage3726en_US
dc.identifier.urihttps://doi.org/10.1016/j.transproceed.2009.06.224
dc.identifier.urihttps://hdl.handle.net/20.500.14551/24867
dc.identifier.volume41en_US
dc.identifier.wosWOS:000272123900037en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofTransplantation Proceedingsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectClinical Impacten_US
dc.subjectCyclosporineen_US
dc.subjectNephrotoxicityen_US
dc.titleElectrolyte Free Water Clearance Could Be an Early Sign of Renal Dysfunction in Renal Transplant Patientsen_US
dc.typeArticleen_US

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