The effects of intracoronary administration of vitamin E on myocardial ischemia-reperfusion injury during coronary artery surgery

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dc.authoridSunar, Hasan/0000-0002-1276-8549
dc.authoridCIKIRIKCIOGLU, MUSTAFA/0000-0003-1143-347X
dc.authorwosidSunar, Hasan/A-8685-2018
dc.contributor.authorCanbaz, S
dc.contributor.authorDuran, E
dc.contributor.authorEge, T
dc.contributor.authorSunar, H
dc.contributor.authorCikirikcioglu, M
dc.contributor.authorAcipayam, M
dc.date.accessioned2024-06-12T11:17:12Z
dc.date.available2024-06-12T11:17:12Z
dc.date.issued2003
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBackground: Vitamin E has a strong antioxidant capacity, and has been used in several ischemia-reperfusion studies. The aim of this study was to investigate the effects of water-soluble vitamin E (alpha-tocopherol) on myocardial protection during coronary artery surgery. Methods: Water soluble vitamin E (100mg) in tepid saline (n = 14) or tepid saline alone (n = 16) was administered into the coronary arteries at the end of aortic cross-clamping. Cardiac troponin-1 (cTn-1), MB-isoenzyme of creatine kinase (CK-MB), myoglobin, blood gas, and lactate levels in systemic and coronary sinus blood and hemodynamic variables were assessed during and after the operation. Results: Eight hours after reperfusion, cTn-1 levels increased to 3.06 +/- 1.8 ng/ml and 6.97 +/- 3.9 ng/ml in the vitamin E group and control group, respectively (p = 0.01). Coronary sinus lactate concentration was 2.68 +/- 0.5 mmol/l in the vitamin E group and 4.01 +/- 1.5 mmol/l in the control group 60 minutes after reperfusion (p = 0.027). Conclusions: Administration of vitamin E into the coronary arteries before removal of the aortic cross-clamp can reduce myocardial cell injury and protect the myocardium from ischemia-reperfusion injury.en_US
dc.identifier.doi10.1055/s-2003-38983
dc.identifier.endpage61en_US
dc.identifier.issn0171-6425
dc.identifier.issn1439-1902
dc.identifier.issue2en_US
dc.identifier.pmid12730811en_US
dc.identifier.scopus2-s2.0-0038445230en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage57en_US
dc.identifier.urihttps://doi.org/10.1055/s-2003-38983
dc.identifier.urihttps://hdl.handle.net/20.500.14551/24592
dc.identifier.volume51en_US
dc.identifier.wosWOS:000183038900001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherGeorg Thieme Verlag Kgen_US
dc.relation.ispartofThoracic And Cardiovascular Surgeonen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectVitamin Een_US
dc.subjectAlpha Tocopherolen_US
dc.subjectTroponin Ien_US
dc.subjectLactateen_US
dc.subjectIschemia-Reperfusion Injuryen_US
dc.subjectCoronary Artery Bypass Graftingen_US
dc.subjectTroponin-I Releaseen_US
dc.subjectAlpha-Tocopherolen_US
dc.subjectDouble-Blinden_US
dc.subjectHearten_US
dc.subjectCardioplegiaen_US
dc.subjectPreventionen_US
dc.subjectOperationsen_US
dc.titleThe effects of intracoronary administration of vitamin E on myocardial ischemia-reperfusion injury during coronary artery surgeryen_US
dc.typeArticleen_US

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