The papulopustular lesion/arthritis cluster of Behcet's syndrome also clusters in families

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dc.authoridHatemi, Gulen/0000-0002-1952-1135
dc.authoridKaraca, Mehmet/0000-0001-5078-5166
dc.authorwosidHatemi, Gulen/AFM-7014-2022
dc.authorwosidHatemi, Gulen/AAC-9647-2021
dc.contributor.authorKaraca, Mehmet
dc.contributor.authorHatemi, Gulen
dc.contributor.authorSut, Necdet
dc.contributor.authorYazici, Hasan
dc.date.accessioned2024-06-12T10:54:21Z
dc.date.available2024-06-12T10:54:21Z
dc.date.issued2012
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjective. We have previously reported distinct symptom clusters among our patients with Behcet's syndrome (BS). The presence of such clusters suggests that more than one pathogenetic mechanism might be operative in BS. Increases in the frequency of certain clusters in familial BS cases, if present, would further support this notion. To test this hypothesis, we compared the frequency of symptom clusters between familial (Group F) and non-familial (Group NF) cases of BS. Methods. We identified 380 BS patients who had reported a first-degree relative by reviewing 6031 patient charts. We were able to contact 186 (Group F). From the same initial pool, 500 patients were randomly selected. Of those, patients who did not report a family history of BS and who had attended our clinic during the previous 3 months made up Group NF (n = 221). Both groups were questioned about their symptoms within the previous 3 months. Data were analysed using factor analysis, cluster analysis and chi(2) tests. Results. The make-up of the symptom clusters were very similar for the factor and the cluster analyses. The frequency of papulopustular lesions and joint involvement cluster was significantly higher in Group F (39.2 vs 21.5%, P < 0.001). Furthermore, the same cluster was shared in 5/17 related pairs from Group F and in only 5/110 unrelated pairs from Group NF [29 vs 4.5%, P = 0.004; risk ratio (RR) = 6.47, 95% CI 2.15, 18.89]. Conclusion. The papulopustular lesions and arthritis cluster in BS appears to cluster in familial BS as well. This further supports the notion that the pathogenesis of BS may entail several distinct mechanisms resulting in separate phenotype clusters.en_US
dc.identifier.doi10.1093/rheumatology/ker423
dc.identifier.endpage1060en_US
dc.identifier.issn1462-0324
dc.identifier.issn1462-0332
dc.identifier.issue6en_US
dc.identifier.pmid22286924en_US
dc.identifier.scopus2-s2.0-84861463761en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1053en_US
dc.identifier.urihttps://doi.org/10.1093/rheumatology/ker423
dc.identifier.urihttps://hdl.handle.net/20.500.14551/19015
dc.identifier.volume51en_US
dc.identifier.wosWOS:000304200100017en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherOxford Univ Pressen_US
dc.relation.ispartofRheumatologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBehcet's Syndromeen_US
dc.subjectFactor Analysisen_US
dc.subjectDisease Clusteringen_US
dc.subjectDisease Featuresen_US
dc.subjectSkin-Lesionsen_US
dc.subjectArthritisen_US
dc.subjectAggregationen_US
dc.subjectAcneen_US
dc.titleThe papulopustular lesion/arthritis cluster of Behcet's syndrome also clusters in familiesen_US
dc.typeArticleen_US

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