Evaluation of Relationship Between SOD1 50-bp Deletion Gene Polymorphism, Cu, Zn Level, and Viscosity in Postmenopausal Osteoporosis Patients with Vertebral Fractures

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dc.authoridbudak, metin/0000-0002-5968-2048
dc.authoridSOYOCAK, Ahu/0000-0003-0999-2774
dc.authoridDUZGUN ERGUN, DILEK/0000-0002-6245-6631
dc.authorwosidBudak, metin/Z-3010-2019
dc.authorwosidSOYOCAK, Ahu/Q-1726-2015
dc.contributor.authorSoyocak, Ahu
dc.contributor.authorDoganer, Fulya
dc.contributor.authorErgun, Dilek Duzgun
dc.contributor.authorBudak, Metin
dc.contributor.authorCosan, Didem Turgut
dc.contributor.authorOzgen, Merih
dc.date.accessioned2024-06-12T11:11:47Z
dc.date.available2024-06-12T11:11:47Z
dc.date.issued2023
dc.departmentTrakya Üniversitesien_US
dc.description.abstractOxidative stress plays a role in the pathogenesis of bone loss, causing low bone mineral density (BMD) and associated osteoporotic fractures. In our study, we aimed to investigate the relationship of SOD1 50-bp insertion( Ins)/deletion( Del) polymorphism that is involved in oxidative stress metabolism, Cu and Zn element concentrations, and plasma viscosity level, with postmenopausal osteoporosis and related vertebral fractures. The study included 167 voluntary individuals. The 50- bp Ins/Del polymorphism of SOD1 was determined by allele-specific PCR. Plasma Cu and Zn levels were measured by atomic absorption spectrophotometry (AAS). The plasma viscosity was determined using the Harkness Capillary Viscometer device. In our study, the distribution of SOD1 promoter 50-bp Ins/Del polymorphism did not indicate a significant difference between the groups and in postmenopausal osteoporosis patients with and without fractures (p > 0.05). The Ins/Ins genotype was found to be common in individuals in both groups. The Cu and Zn levels of the study group were found to be between the normal reference values (p > 0.05). It was determined that plasma viscosity increased significantly in the group of osteoporotic patients and in patients with postmenopausal osteoporosis with fractures (p < 0.01). In addition, plasma viscosity was found to significantly increase in patients with Ins/Ins genotype and fractures (p < 0.01). Postmenopausal osteoporosis and associated vertebral fracture were found not to be directly related to SOD1 50-bp polymorphism and Cu and Zn element levels. Plasma viscosity levels were found to increase due to the increase in oxidative stress products. Further studies are needed to clarify the roles and relationships of SOD genes and trace elements in the development of postmenopausal osteoporosis and vertebral fracture.en_US
dc.identifier.doi10.1007/s12011-022-03185-8
dc.identifier.endpage610en_US
dc.identifier.issn0163-4984
dc.identifier.issn1559-0720
dc.identifier.issue2en_US
dc.identifier.pmid35243588en_US
dc.identifier.scopus2-s2.0-85125529981en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage603en_US
dc.identifier.urihttps://doi.org/10.1007/s12011-022-03185-8
dc.identifier.urihttps://hdl.handle.net/20.500.14551/22926
dc.identifier.volume201en_US
dc.identifier.wosWOS:000763826600001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringernatureen_US
dc.relation.ispartofBiological Trace Element Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectOsteoporosisen_US
dc.subjectFractureen_US
dc.subjectSOD1en_US
dc.subjectPolymorphismen_US
dc.subjectCuen_US
dc.subjectZnen_US
dc.subjectPlasma Viscosityen_US
dc.subjectBone-Mineral Densityen_US
dc.subjectOxidative Stressen_US
dc.subjectSuperoxide Dismutase-1en_US
dc.subjectPromoter Regionen_US
dc.subjectBlood-Viscosityen_US
dc.subjectTrace-Elementsen_US
dc.subjectAssociationen_US
dc.subjectWomenen_US
dc.subjectZincen_US
dc.subjectSusceptibilityen_US
dc.titleEvaluation of Relationship Between SOD1 50-bp Deletion Gene Polymorphism, Cu, Zn Level, and Viscosity in Postmenopausal Osteoporosis Patients with Vertebral Fracturesen_US
dc.typeArticleen_US

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