Evaluation of swallowing function with clinical and dosimetric parameters in head and neck cancer patients receiving radio (chemo)therapy

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dc.authoridTürkkan, Görkem/0000-0002-9084-2599
dc.authorwosidTürkkan, Görkem/AAM-6705-2021
dc.authorwosidTürkkan, Görkem/E-7048-2017
dc.contributor.authorTurkkan, G.
dc.contributor.authorCaloglu, M.
dc.contributor.authorYurut-Caloglu, V
dc.contributor.authorKarasalihoglu, A. R.
dc.contributor.authorDogan, M.
dc.contributor.authorUzal, C.
dc.date.accessioned2024-06-12T10:59:56Z
dc.date.available2024-06-12T10:59:56Z
dc.date.issued2019
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBackground: This study aimed to evaluate the relationship between late dysphagia and dosimetric-clinical parameters in patients receiving radiotherapy for head and neck cancer (HNC). Materials and Methods: Twenty-six HNC patients treated with three-dimensional conformal radiotherapy were evaluated. A total dose of 66-70 Gy in 33-35 fractions was administered for curative purposes. Six swallowing organs at risk were contoured for each patient: the superior, middle and inferior pharyngeal constrictor muscles (SPCM, MPCM and IPCM); the cervical oesophagus (CE); the base of tongue (BOT); and the larynx. The mean dose in Gray [Dmean (Gy)], maximum dose in Gray [Dmax(Gy)] and percentages of organ volumes receiving >= 50 Gy, >= 60 Gy and >= 70 Gy [V50 (%), V60 (%) and V70 (%), respectively] were calculated from the dose-volume histograms for each structure. Dysphagia was evaluated using video laryngoscopy, the European Organization for Research and Treatment of Cancer quality of life module for HNC and the Leipzig scale. Results: Dmean, V60 and V70 for the BOT; Dmean and V60 for the SPCM; Dmean, Dmax, V60 and V70 for the IPCM; Dmean, Dmax, V60 and V70 for the larynx; and Dmean, Dmax, V50 and V70 for the CE were correlated with the presence of pharyngeal secretion. Only V50 for the CE was correlated with abnormal glottic closure. Dmean, Dmax, V60 and V70 for the BOT and the SPCM were correlated with liquid swallowing problems. Dmax for the MPCM; Dmean, Dmax, V60 and V70 for the IPCM; and Dmax, V60 and V70 for the CE were correlated with the Leipzig score. Conclusion: The dose-volume parameters of swallowing organs were found to be associated with different rates of late dysphagia in HNC patients receiving radiotherapy. The identification of dosimetric parameters that predict late dysphagia is not adequate yet. Well-designed multi-institutional studies are necessary to clarify the dose-volume constraints.en_US
dc.identifier.doi10.18869/acadpub.ijrr.17.3.625
dc.identifier.endpage632en_US
dc.identifier.issn2322-3243
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-85076367741en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage625en_US
dc.identifier.urihttps://doi.org/10.18869/acadpub.ijrr.17.3.625
dc.identifier.urihttps://hdl.handle.net/20.500.14551/20639
dc.identifier.volume17en_US
dc.identifier.wosWOS:000492396700012en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherIjrr-Iranian Journal Radiation Resen_US
dc.relation.ispartofInternational Journal Of Radiation Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDysphagiaen_US
dc.subjectHead And Neck Canceren_US
dc.subjectRadiotherapyen_US
dc.subjectLong-Term Dysphagiaen_US
dc.subjectDefinitive Radiotherapyen_US
dc.subjectDelineationen_US
dc.subjectDysfunctionen_US
dc.subjectIntensityen_US
dc.titleEvaluation of swallowing function with clinical and dosimetric parameters in head and neck cancer patients receiving radio (chemo)therapyen_US
dc.typeArticleen_US

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