Predictive value of thyroid hormones on the first day in adult respiratory distress syndrome patients admitted to ICU

Basit Öğe Kaydı
dc.contributor.authorTüre, M
dc.contributor.authorMemis, D
dc.contributor.authorKurt, I
dc.contributor.authorPamukçu, Z
dc.date.accessioned2024-06-12T11:19:12Z
dc.date.available2024-06-12T11:19:12Z
dc.date.issued2005
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBACKGROUND: Thyroid hormone dysfunction could affect outcome and increase mortality in critical illness. Therefore, in a prospective, observational study we analyzed and compared the prognostic accuracy of free tri-iodothyronine (M), free thyroxine (M), thyroid-stimulating hormone (TSH), along with the APACHE II and SOFA scoring systems in predicting intensive care unit (ICU) mortality in critically ill patients. PATIENTS AND METHODS: Physiology scores were calculated for the first 24 hours after ICU admission in 206 patients with acute respiratory distress syndrome. APACHE 11 and SOFA scores were employed to determine the initial severity of illness. Thyroid hormones were measured within the first 24 hours. Logistic regression models were created for APACHE 11 scores, SOFA scores, and thyroid hormone levels. The models predicted high- and low-risk subgroups. Models that showed a good fit were stratified by Kaplan-Meier survival curves. RESULTS:There were 98 (47.6%) survivors and 108 (52.4%) non-survivors. The survivors had a lower APACHE 11 score (11.50 vs 15.82, P < 0.0005), a lower SOFA score (6.06 vs 9.42, P < 0.0005), a younger age (57 vs 70 years, P=4.008), a shorter ICU stay (13 vs 16 days, P=4.012), and a higher fT3 level (2.18 vs 1.72 pg/mL, P=4.002) than non-survivors. ICU survival was most closely predicted by a model that included age and fT3 and a model that included APACHE 11 and APACHE II*sex. CONCLUSION: In critically ill patients, serum fT3 concentrations markedly decreased after ICU admission among non-survivors. According to our findings, fT3 levels might have additive discriminatory power to age, SOFA and APACHE 11 scores in predicting short-term mortality in ARDS patients admitted to ICU.en_US
dc.identifier.doi10.5144/0256-4947.2005.466
dc.identifier.endpage472en_US
dc.identifier.issn0256-4947
dc.identifier.issn1319-9226
dc.identifier.issue6en_US
dc.identifier.pmid16438455en_US
dc.identifier.scopus2-s2.0-30944448906en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage466en_US
dc.identifier.urihttps://doi.org/10.5144/0256-4947.2005.466
dc.identifier.urihttps://hdl.handle.net/20.500.14551/25101
dc.identifier.volume25en_US
dc.identifier.wosWOS:000234842200004en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherK Faisal Spec Hosp Res Centreen_US
dc.relation.ispartofAnnals Of Saudi Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectIntensive-Care Uniten_US
dc.subjectCritical Illnessen_US
dc.subjectCritically-Illen_US
dc.subjectOutcome Predictionen_US
dc.subjectFunction Testsen_US
dc.subjectSaps-Iien_US
dc.subjectMortalityen_US
dc.subjectSurvivalen_US
dc.titlePredictive value of thyroid hormones on the first day in adult respiratory distress syndrome patients admitted to ICUen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu