The Impact of Total Tumor Diameter on Lymph Node Metastasis and Tumor Recurrence in Papillary Thyroid Carcinomas

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dc.authoridAYYILDIZ MERCAN, Meltem/0000-0003-1329-3431
dc.authoridayturk, semra/0000-0002-1560-3459
dc.authorwosidANDAÇ, BURAK/JEO-6641-2023
dc.authorwosidayturk, semra/U-4265-2017
dc.contributor.authorCan, Nuray
dc.contributor.authorBulbul, Buket Yilmaz
dc.contributor.authorOzyilmaz, Filiz
dc.contributor.authorSut, Necdet
dc.contributor.authorMercan, Meltem Ayyildiz
dc.contributor.authorAndac, Burak
dc.contributor.authorCelik, Mehmet
dc.date.accessioned2024-06-12T11:12:02Z
dc.date.available2024-06-12T11:12:02Z
dc.date.issued2024
dc.departmentTrakya Üniversitesien_US
dc.description.abstract(1) Introduction: The impact of multifocality/bilaterality on the prognosis of papillary thyroid carcinoma (PTC) is a matter of debate. In order to clarify this debate, several studies have attempted to identify additional parameters associated with poor prognosis, including total tumor diameter (TTD), in the context of multifocal PTCs. In this context, this study was carried out to investigate the impact of TTD on tumor recurrence and lymph node metastasis (LNM) in PTCs. (2) Materials and Methods: The sample of this single-center retrospective study consisted of 706 patients diagnosed with PTC. TTD was calculated as the sum of the largest diameters of tumor foci in multifocal tumors. The resulting TTDs were grouped into TTDs <= 10 mm, TTDs > 10 mm, TTDs <= 20 mm, and TTDs > 20 mm, using 10 mm and 20 mm as cutoff values. (3) Results: There was no significant difference between multifocal papillary microcarcinomas (PTMCs) with a TTD of >10 mm and unifocal PTCs with a primary tumor diameter (PTD) of >10 mm except for advanced age and lymphovascular invasion (LVI). In addition, perineural invasion (PNI) and TTD > 10 mm were found to be significant risk factors for LNM, and PNI, TTD > 10 mm, TTD > 20 mm, and bilaterality were found to be significant risk factors for recurrence. LVI, and TTD > 10 mm were found to be independent significant predictors for recurrence, and LVI and extrathyroidal extension (ETE) were found to be independent significant predictors for LNM. (4) Conclusions: Considering TTD > 10 mm in recurrence risk categorization models and adopting a clinical approach that takes into account multifocal PTMCs with TTD > 10 mm along with unifocal PTCs with PTD > 10 mm may be more useful in terms of clinical management of the disease.en_US
dc.identifier.doi10.3390/diagnostics14030272
dc.identifier.issn2075-4418
dc.identifier.issue3en_US
dc.identifier.pmid38337788en_US
dc.identifier.scopus2-s2.0-85184723506en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.3390/diagnostics14030272
dc.identifier.urihttps://hdl.handle.net/20.500.14551/23016
dc.identifier.volume14en_US
dc.identifier.wosWOS:001159386800001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMdpien_US
dc.relation.ispartofDiagnosticsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPapillary Thyroid Carcinomaen_US
dc.subjectMultifocalityen_US
dc.subjectBilateralityen_US
dc.subjectTotal Tumor Diameteren_US
dc.subjectNumber Of Tumor Focien_US
dc.subjectPerineural Invasionen_US
dc.subjectClinicopathological Featuresen_US
dc.subjectRisk-Factorsen_US
dc.subjectIntraglandular Disseminationen_US
dc.subjectAssociation Guidelinesen_US
dc.subjectStaging Systemen_US
dc.subject8th Editionen_US
dc.subjectMultifocalityen_US
dc.subjectCanceren_US
dc.subjectNumberen_US
dc.subjectFocien_US
dc.titleThe Impact of Total Tumor Diameter on Lymph Node Metastasis and Tumor Recurrence in Papillary Thyroid Carcinomasen_US
dc.typeArticleen_US

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