The effect of hyperbaric oxygen treatment on aspiration pneumonia

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dc.authoridŞenol, Mehmet Güney/0000-0001-6397-9293
dc.authoridColak, Alkin/0000-0001-9103-4844
dc.authoridbasaran, umit nusret/0000-0002-9977-6655
dc.authorwosidŞenol, Mehmet Güney/L-9182-2015
dc.authorwosidGuzel, Ahmet/AGE-2880-2022
dc.authorwosidColak, Alkin/R-8739-2017
dc.contributor.authorSahin, Sevtap Hekimoglu
dc.contributor.authorKanter, Mehmet
dc.contributor.authorAyvaz, Suleyman
dc.contributor.authorColak, Alkin
dc.contributor.authorAksu, Burhan
dc.contributor.authorGuzel, Ahmet
dc.contributor.authorBasaran, Umit Nusret
dc.date.accessioned2024-06-12T11:13:07Z
dc.date.available2024-06-12T11:13:07Z
dc.date.issued2011
dc.departmentTrakya Üniversitesien_US
dc.description.abstractWe have studied whether hyperbaric oxygen (HBO) prevents different pulmonary aspiration materials-induced lung injury in rats. The experiments were designed in 60 Sprague-Dawley rats, ranging in weight from 250 to 300 g, randomly allotted into one of six groups (n = 10): saline control, Biosorb Energy Plus (BIO), hydrochloric acid (HCl), saline + HBO treated, BIO + HBO treated, and HCl + HBO treated. Saline, BIO, HCl were injected into the lungs in a volume of 2 ml/kg. A total of seven HBO sessions were performed at 2,4 atm 100% oxygen for 90 min at 6-h intervals. Seven days later, rats were sacrificed, and both lungs in all groups were examined biochemically and histopathologically. Our findings show that HBO inhibits the inflammatory response reducing significantly (P < 0.05) peribronchial inflammatory cell infiltration, alveolar septal infiltration, alveolar edema, alveolar exudate, alveolar histiocytes, interstitial fibrosis, granuloma, and necrosis formation in different pulmonary aspiration models. Pulmonar aspiration significantly increased the tissue HP content, malondialdehyde (MDA) levels and decreased (P < 0.05) the antioxidant enzyme (SOD, GSH-Px) activities. HBO treatment significantly (P < 0.05) decreased the elevated tissue HP content, and MDA levels and prevented inhibition of SOD, and GSH-Px (P < 0.05) enzymes in the tissues. Furthermore, there is a significant reduction in the activity of inducible nitric oxide synthase, TUNEL and arise in the expression of surfactant protein D in lung tissue of different pulmonary aspiration models with HBO therapy. It was concluded that HBO treatment might be beneficial in lung injury, therefore, shows potential for clinical use.en_US
dc.description.sponsorshipTrakya University Research Center, Edirne, Turkey [TUBAB 2010-179]en_US
dc.description.sponsorshipThis study was supported as Project TUBAB 2010-179 by Trakya University Research Center, Edirne, Turkey.en_US
dc.identifier.doi10.1007/s10735-011-9334-6
dc.identifier.endpage310en_US
dc.identifier.issn1567-2379
dc.identifier.issn1567-2387
dc.identifier.issue4en_US
dc.identifier.pmid21656021en_US
dc.identifier.scopus2-s2.0-80052567523en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage301en_US
dc.identifier.urihttps://doi.org/10.1007/s10735-011-9334-6
dc.identifier.urihttps://hdl.handle.net/20.500.14551/23432
dc.identifier.volume42en_US
dc.identifier.wosWOS:000292835900002en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofJournal Of Molecular Histologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPulmonary Aspirationen_US
dc.subjectInosen_US
dc.subjectSurfactant Protein Den_US
dc.subjectTUNELen_US
dc.subjectHyperbaric Oxygenen_US
dc.subjectInduced Lung Injuryen_US
dc.subjectNitric-Oxide Synthaseen_US
dc.subjectPulmonary Aspirationen_US
dc.subjectEnteral Solutionsen_US
dc.subjectGastric Contentsen_US
dc.subjectProtein-Den_US
dc.subjectAssayen_US
dc.subjectPathogenesisen_US
dc.subjectBlueen_US
dc.titleThe effect of hyperbaric oxygen treatment on aspiration pneumoniaen_US
dc.typeArticleen_US

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