Spleen tyrosine kinase inhibition prevents tissue damage after ischemia-reperfusion

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dc.authoridLapchak, Peter/0000-0001-8597-088X
dc.authorwosidLapchak, Peter H./JCE-0582-2023
dc.authorwosidLapchak, Peter H./B-3559-2009
dc.authorwosidtsokos, george C/O-3360-2013
dc.contributor.authorPamuk, Omer Nuri
dc.contributor.authorLapchak, Peter H.
dc.contributor.authorRani, Poonam
dc.contributor.authorPine, Polly
dc.contributor.authorLucca, Jurandir J. Dalle
dc.contributor.authorTsokos, George C.
dc.date.accessioned2024-06-12T11:15:55Z
dc.date.available2024-06-12T11:15:55Z
dc.date.issued2010
dc.departmentTrakya Üniversitesien_US
dc.description.abstractPamuk ON, Lapchak PH, Rani P, Pine P, Dalle Lucca JJ, Tsokos GC. Spleen tyrosine kinase inhibition prevents tissue damage after ischemia-reperfusion. Am J Physiol Gastrointest Liver Physiol 299: G391-G399, 2010. First published June 3, 2010; doi: 10.1152/ajpgi.00198.2010.-Reperfusion injury to tissue following an ischemic event occurs as a consequence of an acute inflammatory response that can cause significant morbidity and mortality. Components of both the innate (complement, immunoglobulin, monocytes, and neutrophils) and adaptive (B and T lymphocytes) immune systems have been demonstrated to mediate tissue injury. Spleen tyrosine kinase (Syk) is responsible for membrane-mediated signaling in various cell types including B lymphocytes, macrophages, and T cells. We investigated the ability of a small drug Syk inhibitor, R788, to protect mice against mesenteric ischemia-reperfusion (I/R)-induced local (intestine) and remote lung injury. Mice were fed with chow containing a Syk inhibitor for 6 days before the performance of intestinal I/R, which resulted in silencing of the expression of the active phosphorylated Syk. Syk inhibition significantly suppressed both local and remote lung injury. The beneficial effect was associated with reduced IgM and complement 3 deposition in the tissues and significant reduction of polymorphonuclear cell infiltration. Our data place Syk upstream of events leading to the binding of natural antibodies to the ischemia-conditioned tissues and urge the consideration of the use of Syk inhibitors in the prevention or improvement of tissue injury of organs exposed to ischemia or hypoperfusion.en_US
dc.description.sponsorshipMedical Research and Material Command of the Department of the Army [W81XWH-09-1-0530]; TUBITAKen_US
dc.description.sponsorshipResearch was supported by Grant W81XWH-09-1-0530 from Medical Research and Material Command of the Department of the Army. O. N. Pamuk was supported by TUBITAK Scholar.en_US
dc.identifier.doi10.1152/ajpgi.00198.2010
dc.identifier.endpageG399en_US
dc.identifier.issn0193-1857
dc.identifier.issn1522-1547
dc.identifier.issue2en_US
dc.identifier.pmid20522642en_US
dc.identifier.scopus2-s2.0-77955622884en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpageG391en_US
dc.identifier.urihttps://doi.org/10.1152/ajpgi.00198.2010
dc.identifier.urihttps://hdl.handle.net/20.500.14551/24120
dc.identifier.volume299en_US
dc.identifier.wosWOS:000280483200012en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAmer Physiological Socen_US
dc.relation.ispartofAmerican Journal Of Physiology-Gastrointestinal And Liver Physiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectSyken_US
dc.subjectSyk Inhibitionen_US
dc.subjectR788en_US
dc.subjectSyk Kinaseen_US
dc.subjectComplementen_US
dc.subjectExpressionen_US
dc.subjectInjuryen_US
dc.subjectNeutrophilsen_US
dc.subjectAutoimmuneen_US
dc.subjectAntibodyen_US
dc.subjectTargeten_US
dc.subjectIgmen_US
dc.titleSpleen tyrosine kinase inhibition prevents tissue damage after ischemia-reperfusionen_US
dc.typeArticleen_US

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