The Effect of Intrauterine Antipsychotic Drug Exposure on Learning and Memory in Adult Rats

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dc.authoridOltulu, Cagatay/0000-0002-6051-3479
dc.authoridKaradag, Cetin Hakan/0000-0002-4763-986X
dc.authorwosidOltulu, Cagatay/V-1823-2018
dc.authorwosidKaradag, Cetin Hakan/H-4899-2013
dc.contributor.authorOltulu, Cagatay
dc.contributor.authorKaradag, Cetin Hakan
dc.date.accessioned2024-06-12T11:07:33Z
dc.date.available2024-06-12T11:07:33Z
dc.date.issued2016
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjective: The effects of antipsychotic drugs, of whose different classes can be used in the treatment of patients with resistant to schizophrenia, on the fetus and the benefits of the treatment to the mother should be taken into consideration before making a decision about initiating treatment. This study aimed to examine the effects of prenatal exposure to various antipsychotic agents on learning and memory in adult rats. Method: In this study, antipsychotic drugs from different chemical classes (2 mg/kg haloperidol, 100 mg/kg thioridazine, 200 mg/kg sulpiride, 20 mg/kg chlorprothixene, 40 mg/kg clozapine, 10 mg/kg fluphenazine, 20 mg/kg chlorpromazine) and water for the control group were administered to pregnant Sprague-Dawley dams through gavage during the pregnancy period. In total, 16 groups were created and tested in the Morris water maze by dividing offspring of eight mother rats into male and female rat groups (n=10) on postpartum day 60. Learning was tested with hidden platform task and memory was tested with probe test. Results: It has been observed that learning was impaired in the male and female groups that received haloperidol, sulpiride, chlorprothixene, clozapine, and chlorpromazine, as well as in the female groups receiving fluphenazine and thioridazine. Thigmotaxis is the time spent on 10 cm perimeter of the walls of the pool. Thigmotaxis values of all groups were still higher except for the male group of thioridazine on fifth day. Conclusion: These results show that when prenatal exposure to antipsychotics occurs, it causes impairment in the realization of task of finding escape platform properly, rather than affecting learning and memory functions, specifically in their adulthood so that high thigmotaxis may be the reason for deterioration in escape latency parameter.en_US
dc.identifier.doi10.5455/bcp.20160627090254
dc.identifier.endpage373en_US
dc.identifier.issn1017-7833
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-85003467567en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage364en_US
dc.identifier.urihttps://doi.org/10.5455/bcp.20160627090254
dc.identifier.urihttps://hdl.handle.net/20.500.14551/22088
dc.identifier.volume26en_US
dc.identifier.wosWOS:000390418700005en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherKure Iletisim Grubu A Sen_US
dc.relation.ispartofKlinik Psikofarmakoloji Bulteni-Bulletin Of Clinical Psychopharmacologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectLearningen_US
dc.subjectMemoryen_US
dc.subjectAntipsychoticsen_US
dc.subjectHaloperidolen_US
dc.subjectSulpirideen_US
dc.subjectThioridazineen_US
dc.subjectChlorprothixeneen_US
dc.subjectChlorpromazineen_US
dc.subjectClozapineen_US
dc.subjectFluphenazineen_US
dc.subjectPrenatal Exposureen_US
dc.subjectHaloperidolen_US
dc.subjectHippocampusen_US
dc.subjectPregnancyen_US
dc.subjectRisperidoneen_US
dc.subjectQuetiapineen_US
dc.titleThe Effect of Intrauterine Antipsychotic Drug Exposure on Learning and Memory in Adult Ratsen_US
dc.typeArticleen_US

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