ARE CLINICAL FEATURES IN LOFGREN'S SYNDROME-RELATED ERYTHEMA NODOSUM DIFFERENT FROM IDIOPATHIC ERYTHEMA NODOSUM?

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dc.contributor.authorDonmez, S.
dc.contributor.authorKisacik, B.
dc.contributor.authorPamuk, O. N.
dc.contributor.authorPehlivan, Y.
dc.contributor.authorAydogdu, E.
dc.contributor.authorYurekli, O. A.
dc.contributor.authorOnat, A. M.
dc.date.accessioned2024-06-12T11:07:47Z
dc.date.available2024-06-12T11:07:47Z
dc.date.issued2012
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBackground and Objectives: We retrospectively evaluated acute sarcoidosis (Lofgren's syndrome) patients diagnosed at 2 centers and compared the clinical features of Lofgren's syndrome (LS) related erythema nodosum (EN) to patients with idiopathic IEN who were diagnosed within the same time frame. Methods: Thirty patients (10 males, 20 females) who were diagnosed with LS and were being followed up for the last 8 years at 2 centers were included. Thirty patients (4 males, 26 females) who were admitted to the rheumatology outpatient clinics for IEN during that time period were taken as controls. The clinical and laboratory features at the initial admission, treatment modalities and response were recorded. Results: Twentyfour (80%) patients with LS related EN had arthritis and/or arthralgia. Fifteen of them had only findings of periarticular ankle inflammation and 4 had polyarthritis. When LS related EN patients were compared to IEN patients, the former group had more arthritis and/or arthralgia (p<0.001), leucocytosis (p=0.02), lymphopenia (p=0.005) and thrombocytosis (p=0.05), and higher ESR (p=0.02). Twentyfive (83.3%) patients with LS related EN were administered oral corticosteroids. In 21 patients, hilar lymphadenopathy disappeared on control chest x-ray and CT; in 3 patients, minimal residual lymph node enlargement was persistent. During a median follow-up of 54 months (range: 10-84 months), none of the LS related EN patients had clinical relapse. Conclusions: Apart from BHL, arthritis and/or arthralgia especially periarticular ankle inflammation is the feature which could be used to differentiate LS related EN from IEN. There is more need for steroids in LS patients and the symptoms quickly resolve with steroids.en_US
dc.identifier.endpage131en_US
dc.identifier.issn1124-0490
dc.identifier.issue2en_US
dc.identifier.pmid23461075en_US
dc.identifier.startpage128en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14551/22185
dc.identifier.volume29en_US
dc.identifier.wosWOS:000208896500007en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMattioli 1885en_US
dc.relation.ispartofSarcoidosis Vasculitis And Diffuse Lung Diseasesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectLofgren's Syndromeen_US
dc.subjectSarcoidosisen_US
dc.subjectErythema Nodosumen_US
dc.titleARE CLINICAL FEATURES IN LOFGREN'S SYNDROME-RELATED ERYTHEMA NODOSUM DIFFERENT FROM IDIOPATHIC ERYTHEMA NODOSUM?en_US
dc.typeArticleen_US

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