The effect of lipoic acid in the prevention of myocardial infarction in diabetic rats

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dc.contributor.authorOzgun, E.
dc.contributor.authorOzgun, Sayilan G.
dc.contributor.authorUsta, U.
dc.contributor.authorEskiocak, S.
dc.contributor.authorSut, N.
dc.contributor.authorGokmen, Suer S.
dc.date.accessioned2024-06-12T11:15:41Z
dc.date.available2024-06-12T11:15:41Z
dc.date.issued2018
dc.departmentTrakya Üniversitesien_US
dc.description.abstractOBJECTIVES: We aimed to investigate the effect of lipoic acid in the prevention of myocardial infarction in diabetic rats. METHODS: Rats were divided into five groups as control, ISO, LA+ISO, STZ+ISO and STZ+LA+ISO. To induce diabetes, single dose of streptozotocin was injected to STZ+ISO and STZ+LA+ISO groups. Lipoic acid (10 mg/kg/day) was injected for 14 days to LA+ISO and STZ+LA+ISO groups. To induce myocardial infarction, isoproterenol was injected to ISO, LA+ISO, STZ+ISO and STZ+LA+ISO groups on the days 13 and 14 of lipoic acid treatment. Cardiac necrosis and leucocyte infiltration were investigated histopathologically. Serum malondialdehyde levels, paraoxonase and lactonase activities were measured spectrophotometrically. RESULTS: Isoproterenol caused a significant increase in cardiac necrosis, leucocyte infiltration and serum lipid peroxidation whereas a significant decrease in serum paraoxonase and lactonase activities. In myocardial infarcted non-diabetic rats, while lipoic acid caused a significant decrease in cardiac necrosis, leucocyte infiltration and serum lipid peroxidation and a significant increase in serum paraoxonase and lactonase activities, it did not change these histopathologic or biochemical parameters in myocardial infarcted diabetic rats. CONCLUSION: Lipoic acid, at the dose of 10 mg/kg, is effective to prevent myocardial infarction in non-diabetic rats but it is insufficient in diabetic rats.en_US
dc.identifier.doi10.4149/BLL_2018_119
dc.identifier.endpage669en_US
dc.identifier.issn0006-9248
dc.identifier.issn1336-0345
dc.identifier.issue10en_US
dc.identifier.pmid30345777en_US
dc.identifier.scopus2-s2.0-85055075598en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage664en_US
dc.identifier.urihttps://doi.org/10.4149/BLL_2018_119
dc.identifier.urihttps://hdl.handle.net/20.500.14551/24028
dc.identifier.volume119en_US
dc.identifier.wosWOS:000451638900011en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherComenius Univen_US
dc.relation.ispartofBratislava Medical Journal-Bratislavske Lekarske Listyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectStreptozotocin-Induced Diabetesen_US
dc.subjectLipoic Aciden_US
dc.subjectIsoproterenol-Induced Myocardial Infarctionen_US
dc.subjectLipid Peroxidationen_US
dc.subjectParaoxonaseen_US
dc.subjectLactonaseen_US
dc.subjectOxidative Stressen_US
dc.subjectSerum Paraoxonaseen_US
dc.subjectProtectsen_US
dc.subjectLiveren_US
dc.subjectArylesteraseen_US
dc.subjectPon3en_US
dc.titleThe effect of lipoic acid in the prevention of myocardial infarction in diabetic ratsen_US
dc.typeArticleen_US

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