Ligamentum flavum fibrozisindeki kollajen liflerinin ekspresyonundaki değişiklikler ve bu değişikliklerin miRNA'lar ile ilişkisi
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Dosyalar
Tarih
2022
Yazarlar
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Yayıncı
Trakya Üniversitesi Tıp Fakültesi
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Omurga kanal darlıg?ı; omurilig?in, onu çevreleyen dokularca bası altında kalmasına bag?lı olarak olus?an bir omurga hastalıg?ıdır. Pek çok nedeni olsa da, omurgada yas?ın ilerlemesi ile beraber göru?len dejenerasyon, bu hastalıg?ın en sık nedenidir. Ligamentum flavum, omurilig?i arka ve yan kısımlarından çevreleyen omurilig?i koruma görevinin yanında omurga biyomekanig?ine katkı sag?layan ligamandır. Dejenerasyon ile beraber ligamentum flavumun hu?cre dıs?ı yatag?ının protein biles?enlerinin yapısı bozulur ve oran kollajen liflerinin lehine deg?is?ir. Ligamentum flavum hipertrofisine fibrozis es?lik eder. Fibrozis ile ilerleyen hastalıklarda kollajen tip 1,3,5,6,8 ekspresyonun arttıg?ı gösterilmis?tir. Çalıs?mamız ligamentum flavum fibrozisinde artan kollajen yapılarının olası miRNA ekspresyonu ile ils?kisini irdelemeyi amaçlamaktadır. Yapılan çalıs?malarda kollajen ekspresyonlarının du?zenlenmesinde miRNA29B, miRNA143, miRNA221, miRNA27B, ADAMTS2, TNXB, SLC39A1 gibi birçok mikro RNA ve yapısal du?zenleyici protein ilis?kili gösterilmis?tir. Çalıs?mamız lomber dar kanal hastalarındaki ligamentum flavum stenozunun fizyopatolojisini klinik, radyolojik ve moleku?ler olarak aydınlatmayı amaçlamaktadır. Ligamentum flavum fibrozisi ile ilis?kili kollajen, mi-RNA ları ve kollajen du?zenleyici proteinleri saptayarak hastalıg?ın tanı ve tedavisine katkı sag?layacak teropatik hedef bulmayı amaçlamaktadır.
Spinal canal stenosis; It is a spinal disease that occurs due to the compression of the spinal cord by the surrounding tissues. Although there are many causes, degeneration of the spine with advancing age is the most common cause of this disease. Ligamentum flavum, which surrounds the spinal cord from its posterior and lateral parts, contributes to the biomechanics of the spine as well as protecting the spinal cord. With degeneration, the structure of the protein components of the extracellular bed of the ligamentum flavum deteriorates and the ratio changes in favor of the collagen fibers. Ligamentum flavum hypertrophy is accompanied by fibrosis. It has been shown that the expression of collagen type 1, 3, 5, 6, 8 increases in diseases progressing with fibrosis. Our study aims to examine the relationship of increased collagen structures in ligamentum flavum fibrosis with possible miRNA expression. Studies have shown that many microRNAs such as miRNA29B, miRNA143, miRNA221, miRNA27B, ADAMTS2, TNXB, SLC39A1 are associated with the regulation of collagen expressions our study aims to elucidate the physiopathology of ligamentum flavum stenosis in patients with lumbar stenosis clinically, radiologically and molecularly. It aims to find therapeutic targets that will contribute to the diagnosis and treatment of the disease by detecting collagen and miRNAs associated with ligamentum flavum fibrosis.
Spinal canal stenosis; It is a spinal disease that occurs due to the compression of the spinal cord by the surrounding tissues. Although there are many causes, degeneration of the spine with advancing age is the most common cause of this disease. Ligamentum flavum, which surrounds the spinal cord from its posterior and lateral parts, contributes to the biomechanics of the spine as well as protecting the spinal cord. With degeneration, the structure of the protein components of the extracellular bed of the ligamentum flavum deteriorates and the ratio changes in favor of the collagen fibers. Ligamentum flavum hypertrophy is accompanied by fibrosis. It has been shown that the expression of collagen type 1, 3, 5, 6, 8 increases in diseases progressing with fibrosis. Our study aims to examine the relationship of increased collagen structures in ligamentum flavum fibrosis with possible miRNA expression. Studies have shown that many microRNAs such as miRNA29B, miRNA143, miRNA221, miRNA27B, ADAMTS2, TNXB, SLC39A1 are associated with the regulation of collagen expressions our study aims to elucidate the physiopathology of ligamentum flavum stenosis in patients with lumbar stenosis clinically, radiologically and molecularly. It aims to find therapeutic targets that will contribute to the diagnosis and treatment of the disease by detecting collagen and miRNAs associated with ligamentum flavum fibrosis.
Açıklama
Anahtar Kelimeler
Ligamentum flavum, MicroRNAs, Kollojen, Spinal stenozis, ADAMTS2, TNXB, SLC39A1, Collagen, Spinal stenosis
