Protective effects of ?-lipoic acid and L-carnitine in liver ischemia/reperfusion injury

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dc.contributor.authorOzgun, Gulben Sayilan
dc.contributor.authorOzgun, Eray
dc.contributor.authorBasaran, Usmit Nusret
dc.contributor.authorAltaner, Semsi
dc.contributor.authorSut, Necdet
dc.contributor.authorEskiocak, Sevgi
dc.date.accessioned2024-06-12T11:07:45Z
dc.date.available2024-06-12T11:07:45Z
dc.date.issued2014
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjective: Oxidative stress plays an important role in the pathogenesis of liver ischemia/reperfusion injury. Thus, antioxidant treatment can be protective against to liver ischemia/reperfusion injury. The aim of this study to investigate the effects of alpha-lipoic acid and L-carnitine on liver total oxidant status, lipid peroxidation, protein oxidation, neutrophil infiltration and hepatic necrosis in liver ischemia/reperfusion model. Methods: Wistar albino male rats were divided into four groups randomly: Sham (n=7), ischemia/reperfusion (n=7), alpha-lipoic acid (n=8) and L-carnitine (n=8). alpha-Lipoic acid (100 mg/kg) and L-carnitine (100 mg/kg) were given intraperitoneally to alpha-lipoic acid group 15 minutes before and to L-carnitine group 30 minutes before ischemia/reperfusion protocol, respectively. To induce hepatic ischemia/reperfusion injury, ischemia (60 minutes) and reperfusion (30 minutes) were applied to all groups except sham group. Total oxidant status, malondialdehyde, advanced oxidation protein products and myeloperoxidase levels were measured in ischemic lobes of liver tissues. Hepatic necrosis was scored microscopically. Results: There was no significant change in myeloperoxidase levels as an indicator of neutrophil infiltration after reperfusion procedure. Both L-carnitine and alpha-lipoic acid caused a significant decrease in hepatic necrosis. While L-carnitine prevents an increase in total oxidant status, lipid peroxidation and protein oxidation, alpha-lipoic acid prevents only an increase in lipid peroxidation of the liver in hepatic ischemia/reperfusion injury. Conclusion: As a result; we can report that L-carnitine and alpha-lipoic acid have protective effects against to hepatic ischemia/reperfusion injury.en_US
dc.identifier.doi10.5505/tjb.2014.02525
dc.identifier.endpage175en_US
dc.identifier.issn0250-4685
dc.identifier.issn1303-829X
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-84903792890en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage169en_US
dc.identifier.urihttps://doi.org/10.5505/tjb.2014.02525
dc.identifier.urihttps://hdl.handle.net/20.500.14551/22173
dc.identifier.volume39en_US
dc.identifier.wosWOS:000338275000008en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isotren_US
dc.publisherTurkish Biochem Socen_US
dc.relation.ispartofTurkish Journal Of Biochemistry-Turk Biyokimya Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectLiver Ischemia/Reperfusion Injuryen_US
dc.subjectTotal Oxidant Statusen_US
dc.subjectLipid Peroxidationen_US
dc.subjectAdvanced Oxidation Protein Productsen_US
dc.subjectNeutrophil Infiltrationen_US
dc.subjectAlpha-Lipoic Aciden_US
dc.subjectL-Carnitineen_US
dc.subjectIschemia-Reperfusion Injuryen_US
dc.subjectHepatic Ischemiaen_US
dc.subjectOxidative Stressen_US
dc.subjectRatsen_US
dc.subjectMarkeren_US
dc.subjectDamageen_US
dc.titleProtective effects of ?-lipoic acid and L-carnitine in liver ischemia/reperfusion injuryen_US
dc.typeArticleen_US

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