Akne vulgaris olgularında serum prolidaz düzeylerinin incelenmesi
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Dosyalar
Tarih
2016
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Trakya Üniversitesi Tıp Fakültesi
Erişim Hakkı
info:eu-repo/semantics/restrictedAccess
Özet
Akne vulgaris, pilosebase ünitenin en sık kronik enflamatuar hastalığı olup adolesan ve genç erişkinleri % 80'e varan oranda etkilemektedir. Uzun dönemde toplumdan çekilme, depresyon gibi psikiyatrik durumlara ek olarak, tedavisi oldukça maliyetli ve riskli olabilen hatta kalıcı skatrisyel şekil bozukluklarına sebep olabilmektedir. Akne vulgarisin patogenezi multifaktöryeldir ve bu süreçte enflamasyonun rolü belirgindir. Klinik çalışmalarda; doku türüne bakılmaksızın, dokuda kollajen döngüsünün hızlandığı pek çok malign ve kronik enflamatuar süreçte, kollajen yapım ve yıkımında kilit rol oynayan bir enzim olan prolidazın düzey ve aktivitelerinde anlamlı değişiklikler olduğu bildirilmiştir. Bu çalışma akne vulgaris olgularında serum prolidaz düzeylerinin değerlendirildiği ilk çalışmadır. Araştırmada hastalığın şiddeti global akne skorlama sistemiyle değerlendirildi. Klinik şiddete göre gruplanmış (şiddetli-çok şiddetli/orta-hafif şiddetli) akne olguları ve sağlıklı kontrollerde serum prolidaz düzeyi ELISA yöntemiyle ölçüldü. Gruplar arasında yaş açısından anlamlı fark mevcuttu, fakat cinsiyet yönünden anlamlı fark saptanmadı. Serum prolidaz düzeyleri, şiddetli akne grubunda diğer iki gruba göre düşük bulunmakla birlikte, sonuç istatistiksel olarak anlamlı bulunmadı. Sonuç olarak bu çalışma, akne ve kontrol olgularında serum prolidaz düzeylerinin değerlendirildiği ilk çalışma niteliğindedir ve akne vulgarisin patogenezinin daha net anlaşılabilmesiyle tedavide hedefe yönelik yeni çözümler için yol gösterici olabilmesi amacıyla yapılmıştır. Akne vulgaris patogenezinde prolidazın rolünün belirlenmesi için daha geniş vaka serilerinde yeni çalışmalara ihtiyaç vardır.
abstract
Acne vulgaris is the most frequent chronic inflammatory disease of the pilosebaceous unit and the adolescents and young adults are attracted by up to 80 % ratio. In long term, it is inducing psychiatric disorders like withdrawal from society, depression and scatricial deformations of skin which could be treated with high risk and cost or could not be treated completely. The pathogenesis of acne vulgaris is multifactorial and inflammation plays a prominent role in the process. In clinical trials, independent from tissue type; it is found out that prolidase levels and activity are differing in numerous malign and chronic inflammatory processes on which collagen turnover is accelerated. This is the first study investigating serum prolidase levels by acne vulgaris patients. On the research, the severity of disease was evaluated with global acne scoring system. Venous blood specimens were collected from acne patients grouped according to clinical severity and from healthy volunteers. Serum prolidase levels were measured with ELISA process. Significant age difference was determined between groups but no gender difference was found. Serum prolidase levels in severe acne group were lower than the other two groups but that was not statistically significant.As a result, this is the first study evaluating serum prolidase levels by acne and control groups and it is created to gain an insight the pathogenesis of acne vulgaris and for guiding new solutions on its targeted therapy. New studies with wide case series are necessary to determine the role of prolidase on the pathogenesis of acne vulgaris.
abstract
Acne vulgaris is the most frequent chronic inflammatory disease of the pilosebaceous unit and the adolescents and young adults are attracted by up to 80 % ratio. In long term, it is inducing psychiatric disorders like withdrawal from society, depression and scatricial deformations of skin which could be treated with high risk and cost or could not be treated completely. The pathogenesis of acne vulgaris is multifactorial and inflammation plays a prominent role in the process. In clinical trials, independent from tissue type; it is found out that prolidase levels and activity are differing in numerous malign and chronic inflammatory processes on which collagen turnover is accelerated. This is the first study investigating serum prolidase levels by acne vulgaris patients. On the research, the severity of disease was evaluated with global acne scoring system. Venous blood specimens were collected from acne patients grouped according to clinical severity and from healthy volunteers. Serum prolidase levels were measured with ELISA process. Significant age difference was determined between groups but no gender difference was found. Serum prolidase levels in severe acne group were lower than the other two groups but that was not statistically significant.As a result, this is the first study evaluating serum prolidase levels by acne and control groups and it is created to gain an insight the pathogenesis of acne vulgaris and for guiding new solutions on its targeted therapy. New studies with wide case series are necessary to determine the role of prolidase on the pathogenesis of acne vulgaris.
Açıklama
Anahtar Kelimeler
Akne, Prolidaz, Enflamasyon, Acne, Prolidase, Inflammation
