Diagnostic value of liquid-based (Liqui-PREP) preparations and interobserver reproducibility in fine needle aspiration cytology of the nodular thyroid lesions

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dc.authoridCeylan, Şule/0000-0003-1485-3701
dc.authoridErdogan, Nusret/0000-0002-0333-8600
dc.authoridOz Puyan, Fulya/0000-0001-5853-0109
dc.authoridPuyan, Fulya/0000-0001-5853-0109
dc.authorwosidCeylan, Şule/HOC-3896-2023
dc.authorwosidErdogan, Nusret/K-6413-2018
dc.authorwosidOz Puyan, Fulya/A-7077-2018
dc.authorwosidPuyan, Fulya/V-7074-2019
dc.contributor.authorTetikkurt, U. S.
dc.contributor.authorPuyan, F. Oz
dc.contributor.authorOz, F.
dc.contributor.authorErdogan, N.
dc.contributor.authorCeylan, S.
dc.contributor.authorYakupoglu, A.
dc.date.accessioned2024-06-12T11:07:43Z
dc.date.available2024-06-12T11:07:43Z
dc.date.issued2012
dc.departmentTrakya Üniversitesien_US
dc.description.abstractThe aim of this study is to define the diagnostic role of Liqui-Prep (LP) technique for the diagnosis of thyroid lesions and to assess interobserver variabilities. In all, 98 thyroid FNA (fine needle aspiration) cytology samples from 83 patients for preoperative evaluation of thyroid nodules, prepared by the LP, were examined. The LP slides were independently evaluated by three pathologists and they were classified into the five categories according to the Bethesda system. The histopathologic diagnoses were grouped as follows: benign, follicular neoplasm, and malignant. Agreements between LP and histopathologic diagnoses were investigated using kappa values. Marginal homogenity and kappa tests were used for statistical analysis for the evaluation of the agreement between the pathologists and the interobserver variability of the thyroid aspiration cytology results. The presence of nucleoli, nuclear grooving, overlapping, intranuclear inclusion, and nuclear irregularity were recorded and scored on each case based on LP slide review. Concurrences between LP and the histologic diagnoses for the three pathologists were almost perfect (k = 0.798; k = 0.826; k = 0.880). When the observers were paired there was no significant difference from the diagnostic point of view. Interobserver agreement among the three pathologists was moderate. Initially diagnostic difficulties may occur because of the inadequate experience of the pathologists concerning the evaluation of the cytologic changes associated with this new technique. Liqui-Prep technique is useful for the cytologic diagnosis of the thyroid nodules. The nuclear irregularity was the most essential feature for the differentiation of malignant lesions from follicular neoplasm by the LP method. Diagn. Cytopathol. 2011; (C) 2011 Wiley-Liss, Inc.en_US
dc.identifier.doi10.1002/dc.21658
dc.identifier.endpage393en_US
dc.identifier.issn8755-1039
dc.identifier.issue5en_US
dc.identifier.pmid21538948en_US
dc.identifier.scopus2-s2.0-84860644473en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage388en_US
dc.identifier.urihttps://doi.org/10.1002/dc.21658
dc.identifier.urihttps://hdl.handle.net/20.500.14551/22165
dc.identifier.volume40en_US
dc.identifier.wosWOS:000302906900003en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWiley-Blackwellen_US
dc.relation.ispartofDiagnostic Cytopathologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectLiqui-PREPen_US
dc.subjectLiquid-Based Cytologyen_US
dc.subjectThyroiden_US
dc.subjectFine Needle Aspirationen_US
dc.subjectInterobserver Variabilityen_US
dc.subjectLiqui-Prep(Tm)en_US
dc.subjectArtifactsen_US
dc.subjectPitfallsen_US
dc.subjectSmearsen_US
dc.subjectBiopsyen_US
dc.subjectSystemen_US
dc.titleDiagnostic value of liquid-based (Liqui-PREP) preparations and interobserver reproducibility in fine needle aspiration cytology of the nodular thyroid lesionsen_US
dc.typeArticleen_US

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