Long-term effect of curcuminoid treatment on resin-to-dentin bond strength

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dc.authoridTEKBAS ATAY, MELTEM/0000-0002-1762-830X
dc.authoridSeseogullari-Dirihan, Roda/0000-0002-1484-6774
dc.authoridTezvergil-Mutluay, Arzu/0000-0003-0932-8531
dc.authorwosidTEKBAS ATAY, MELTEM/W-7451-2018
dc.authorwosidTezvergil-Mutluay, Arzu/B-4067-2008
dc.contributor.authorAtay, Meltem Tekbas
dc.contributor.authorSeseogullari-Dirihan, Roda
dc.contributor.authorMutluay, Mustafa Murat
dc.contributor.authorTezvergil-Mutluay, Arzu
dc.date.accessioned2024-06-12T10:58:05Z
dc.date.available2024-06-12T10:58:05Z
dc.date.issued2022
dc.departmentTrakya Üniversitesien_US
dc.description.abstractEndogenous dentin proteases contribute to the degradation of collagen fibrils in the hybrid layer. Recently, inhibition of host-derived proteases by curcuminoids has shown promising results. The aim of this study was to evaluate the effect of curcuminoid treatment on the microtensile bond strength (mu TBS) after 24 h or 12 months of storage. Fifty-four extracted sound human molars were flattened to mid-coronal dentin and divided into nine groups. After phosphoric acid-etching for 15 s, the dentin was experimentally treated for 60 s using 100 mu M or 200 mu M of curcumin, diflourobenzocurcumin, or demethoxycurcumin dissolved in 1% and 2% dimethyl sulfoxide (DMSO)/water solutions. Untreated and DMSO-treated groups served as controls. After bonding agent application, each tooth was restored with dental composite. The molars were sectioned into 0.9 x 0.9 x 6 mm beams. The mu TBS testing was performed after 24 h and 12 months of storage in artificial saliva. Data were analyzed using regression analyses. Failure patterns were evaluated using scanning electron microscopy. Dentin treatment with curcuminoids did not adversely affect 24-h mu TBS compared to controls. After 12 months, the mu TBS of curcuminoid groups was statistically significantly higher than the controls. This study indicates the feasibility of using curcuminoids as protease inhibitors.en_US
dc.description.sponsorshipAcademy of Finland [296653]; Turun Yliopistollinen Keskussairaala; Finnish Dental SocietyResearch; ERVA of Tyks Turku University Hospital; Academy of Finland (AKA) [296653] Funding Source: Academy of Finland (AKA)en_US
dc.description.sponsorshipAcademy of Finland, Grant/AwardNumber: #296653; TurunYliopistollinenKeskussairaala; Finnish Dental SocietyResearch; (The expert responsibility area) ERVA funding of TyksTurkuUniversity Hospitalen_US
dc.identifier.doi10.1111/eos.12837
dc.identifier.issn0909-8836
dc.identifier.issn1600-0722
dc.identifier.issue1en_US
dc.identifier.pmid34865272en_US
dc.identifier.scopus2-s2.0-85120484768en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1111/eos.12837
dc.identifier.urihttps://hdl.handle.net/20.500.14551/19937
dc.identifier.volume130en_US
dc.identifier.wosWOS:000726389500001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofEuropean Journal Of Oral Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCollagen Matrix Metalloproteinasesen_US
dc.subjectCurcuminen_US
dc.subjectCysteine Cathepsinsen_US
dc.subjectDegradationen_US
dc.subjectDentinen_US
dc.subjectCross-Linkersen_US
dc.subjectHybrid Layeren_US
dc.subjectDegradationen_US
dc.subjectCollagenen_US
dc.subjectCarbodiimideen_US
dc.subjectMechanismen_US
dc.subjectLinkingen_US
dc.subjectDesignen_US
dc.subjectEdcen_US
dc.titleLong-term effect of curcuminoid treatment on resin-to-dentin bond strengthen_US
dc.typeArticleen_US

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