Insular cortex involvement in migraine patients with chronic pain: A volumetric radiological and clinical study

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dc.authoridKEHAYA, Sezgin/0000-0002-9608-9278
dc.authorwosidKEHAYA, Sezgin/N-9995-2017
dc.contributor.authorMammadkhanli, Orkhan
dc.contributor.authorKehaya, Sezgin
dc.contributor.authorSolak, Serdar
dc.contributor.authorYagmurlu, Kaan
dc.date.accessioned2024-06-12T10:56:31Z
dc.date.available2024-06-12T10:56:31Z
dc.date.issued2024
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBackground: This study aimed to assess abnormalities in the insular cortex of individuals suffering from migraines and examine their associations with pain duration, medication usage, and clinical symptoms. Methods: We analyzed radiological data from 38 migraine patients who had undergone 3D iso T1-weighted brain MRI at our university hospital between 2019 and 2023. Structured questionnaires were used to collect information on participants' age, migraine type, disease duration, clinical symptoms, and medication use. Volumetric analysis was performed on the insular regions using Volbrain and 3DSlicer. The results were statistically analyzed. Results: Comparing groups with chronic pain to normal groups revealed significant differences in several insular regions, including the posterior insula (p = 0.034), parietal operculum (p = 0.04), and the entire insular cortex (p = 0.023). Further group comparisons (Group 1, 2, and 3) showed significant differences in specific insular regions. For instance, the anterior insula (p = 0.032) was associated with taste changes, the posterior insula (p = 0.010) with smell-related changes, and the central operculum (p = 0.046) with sensations of nausea. Additionally, significant changes were observed in the parietal operculum concerning nausea, photophobia, phonophobia, and changes in smell. Conclusion: To the best of our knowledge, there have been no studies investigating the relationship between clinical manifestations and volumetric correlation. This study provides insights into abnormalities in the insular cortex among migraine patients and their potential relevance to pain duration, severity, and migraine type. The results suggest that understanding alterations in insular regions possibly linked to pain could contribute to the development of innovative approaches to managing chronic pain.en_US
dc.identifier.doi10.1016/j.jocn.2024.03.034
dc.identifier.endpage161en_US
dc.identifier.issn0967-5868
dc.identifier.issn1532-2653
dc.identifier.pmid38579522en_US
dc.identifier.scopus2-s2.0-85189511759en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage157en_US
dc.identifier.urihttps://doi.org/10.1016/j.jocn.2024.03.034
dc.identifier.urihttps://hdl.handle.net/20.500.14551/19811
dc.identifier.volume123en_US
dc.identifier.wosWOS:001217886400001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Sci Ltden_US
dc.relation.ispartofJournal Of Clinical Neuroscienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectChronic Painen_US
dc.subjectNeuroimagingen_US
dc.subjectVoxel-Based Morphometry (VBM)en_US
dc.subjectAnterior Insulaen_US
dc.subjectMigraineen_US
dc.subjectSomatotopic Organizationen_US
dc.titleInsular cortex involvement in migraine patients with chronic pain: A volumetric radiological and clinical studyen_US
dc.typeArticleen_US

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