Cutaneous findings in patients with acromegaly and its relationship with concomitant endocrinopathies

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dc.authoridAydemir, Mustafa/0000-0002-5145-0920
dc.authorwosidAydemir, Mustafa/GLS-4728-2022
dc.contributor.authorAn, Isa
dc.contributor.authorKahraman, Filiz Cebeci
dc.contributor.authorBilgic, Asli
dc.contributor.authorAkturk, Aysun Sikar
dc.contributor.authorAlbayrak, Huelya
dc.contributor.authorKartal, Demet
dc.contributor.authorCinar, Salih Levent
dc.date.accessioned2024-06-12T10:50:29Z
dc.date.available2024-06-12T10:50:29Z
dc.date.issued2024
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjectivesSkin changes in acromegaly are often the first sign of the disease. The aim of this study was to describe the cutaneous findings in patients with acromegaly. In addition, a secondary aim was to investigate the possible association of these findings with remission status and concomitant endocrinopathies.Design, Patients, and MeasurementsIn this prospective multicenter study, 278 patients over the age of 18 years with acromegaly who were followed up in 14 different tertiary healthcare institutions were included. These patients, who were followed up by the Endocrinology Department, were then referred to a dermatologist for dermatological examination. The frequency of skin lesions was investigated by detailed dermatologic examination. Dermatological diagnosis is reached by clinical, dermatological and/or dermoscopic examination, and rarely skin punch biopsy examinations in suspicious cases. The possible association of the skin findings between remitted and nonremitted patients and with concomitant endocrinopathies were evaluated.ResultsThe most common skin findings in patients with acromegaly in our study were skin tags (52.5%), cherry angiomas (47.4%), seborrhoea (37%), varicose veins (33%), acneiform lesions (28.8%), hyperhidrosis (26.9%) and hypertrichosis (18.3%). Hypertrichosis was significantly more prevalent in patients nonremitted (p: .001), while xerosis cutis was significantly more prevalent in patients remitted (p: .001). The frequency of diabetes mellitus and hypothyroidism was significantly higher in patients with varicose veins and seborrhoeic keratosis than those without. Additionally, the coexistence of hypothyroidism, hyperthyroidism and galactorrhea was significantly higher in patients with Cherry angioma than in those without Cherry angioma (p-values: .024, .034 and .027, respectively). The frequency of hypogonadism in those with xerosis cutis was significantly higher than in those without (p: .035).ConclusionsCutaneous androgenization findings such as skin tag, seborrhoea, acne and acanthosis nigricans are common in patients with acromegaly. Clinicians should be aware that skin findings associated with insulin resistance may develop in these patients. It can be said that the remission state in acromegaly has no curative effect on cutaneous findings. Only patients in remission were less likely to have hypertrichosis. This may allow earlier review of the follow-up and treatment of acromegaly patients presenting with complaints of hypertrichosis. Additionally, it can be said that patients with skin findings such as cherry angioma may be predisposed to a second endocrinopathy, especially hypothyroidism. Including dermatology in a multidisciplinary perspective in acromegaly patient management would be beneficial to detect cutaneous findings earlier.en_US
dc.identifier.doi10.1111/cen.15071
dc.identifier.issn0300-0664
dc.identifier.issn1365-2265
dc.identifier.pmid38712950en_US
dc.identifier.scopus2-s2.0-85192232601en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1111/cen.15071
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18007
dc.identifier.wosWOS:001217291100001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofClinical Endocrinologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAcromegalyen_US
dc.subjectCherry Angiomaen_US
dc.subjectEndocrinopathyen_US
dc.subjectSkinen_US
dc.subjectSkin Tagen_US
dc.subjectManifestationsen_US
dc.titleCutaneous findings in patients with acromegaly and its relationship with concomitant endocrinopathiesen_US
dc.typeArticleen_US

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