Comparison between low flow sevoflurane anesthesia and total intravenous anesthesia during intermediate-duration surgery: effects on renal and hepatic toxicity

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dc.authoridCinar, Ayse Surhan/0000-0003-2247-9764;
dc.authorwosidcinar, surhan/AAB-8775-2019
dc.authorwosidCinar, Ayse Surhan/AAC-4120-2019
dc.authorwosidOba, Sibel/AAW-9067-2021
dc.contributor.authorSahin, S. H.
dc.contributor.authorCinar, S. O.
dc.contributor.authorPaksoy, I
dc.contributor.authorSut, N.
dc.contributor.authorOba, S.
dc.date.accessioned2024-06-12T10:51:40Z
dc.date.available2024-06-12T10:51:40Z
dc.date.issued2011
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBackground: Renal and hepatic dysfunction or injury might be involved by ether based anesthetic and intravenous anesthetic drug or surgical stress. The purpose of this study is to compare the effect of moderate duration low-flow sevoflurane versus total intravenous anesthesia on renal and hepatic functions. Patients and Methods: Eighty (80) patients between the ages of 25-70 scheduled for elective lumbar disc herniotomy, with an expected operation time of 120-240 min, were enrolled in the study. Anesthesia was induced using remifentanil, propofol and atracurium. Patients were randomly divided into two groups. After intubation, Group S (n=40) received sevoflurane and Group T (n=40) received total intravenous anesthesia with propofol in oxygen and air with a fresh gas flow of 5 L min(-1). Ten minutes after induction the fresh gas flow was decreased to 1L min(-1) in both groups. Serum BUN, creatinine, ALT, AST, LDH and 24 hours excretion of glucose, protein, and creatinine in urine were measured preoperatively and the first three postoperative days. Results: Serum BUN at 48 hours, creatinine at 24, 48. hours, and urine glucose at 24, and 48 hours were significantly higher from the preoperative values in Group S (p<0.05). However, serum BUN and creatinin, urine glucose were within the normal range. There were no significant differences in the renal and hepatic function tests between the groups. Conclusions: These results show that the renal and hepatic effect of moderate duration low-flow sevoflurane and total intravenous anesthesia is similar. Hippokratia 2011; 15 (1): 69-74en_US
dc.identifier.endpage74en_US
dc.identifier.issn1108-4189
dc.identifier.issue1en_US
dc.identifier.pmid21607040en_US
dc.identifier.scopus2-s2.0-79251496468en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage69en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18449
dc.identifier.volume15en_US
dc.identifier.wosWOS:000286283700013en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLithographiaen_US
dc.relation.ispartofHippokratiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAnesthesiaen_US
dc.subjectGeneralen_US
dc.subjectSevofluraneen_US
dc.subjectLowen_US
dc.subjectFlow Anesthesiaen_US
dc.subjectAnalgesicsen_US
dc.subjectOpioiden_US
dc.subjectRemifentanilen_US
dc.subjectPropofolen_US
dc.subjectKidneyen_US
dc.subjectSurgical-Patientsen_US
dc.subjectHepatocellular Integrityen_US
dc.subjectIsoflurane Anesthesiaen_US
dc.subjectDegradation Productsen_US
dc.subjectPropofol Diprivanen_US
dc.subjectVolunteersen_US
dc.subjectDesfluraneen_US
dc.subjectMarkersen_US
dc.subjectRemifentanilen_US
dc.subjectInductionen_US
dc.titleComparison between low flow sevoflurane anesthesia and total intravenous anesthesia during intermediate-duration surgery: effects on renal and hepatic toxicityen_US
dc.typeArticleen_US

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