Role of Oxidative Stress in the Clinical Outcome of Patients with Multiple Blunt Trauma

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dc.authoridBoleken, Mehmet Emin/0000-0001-9006-8364
dc.authoridKaya, Halil/0000-0003-2005-6100;
dc.authorwosidBoleken, Mehmet Emin/ABH-6627-2020
dc.authorwosidGokdemir, Mehmet Tahir/JRX-0261-2023
dc.authorwosidKaya, Halil/ABH-5489-2020
dc.authorwosidCevik, Muazez/X-6543-2018
dc.contributor.authorGokdemir, M. T.
dc.contributor.authorSogut, O.
dc.contributor.authorKaya, H.
dc.contributor.authorSayhan, M. B.
dc.contributor.authorCevik, M.
dc.contributor.authorDokuzoglu, M. A.
dc.contributor.authorBoleken, M. E.
dc.date.accessioned2024-06-12T11:08:46Z
dc.date.available2024-06-12T11:08:46Z
dc.date.issued2012
dc.departmentTrakya Üniversitesien_US
dc.description.abstractOBJECTIVE: This prospective study evaluated serum total oxidant status (TOS), total antioxidant status (TAS) and oxidative stress index (OSI), along with the Revised Trauma Score (RTS) and Injury Severity Score (ISS), as predictors of clinical outcome in the early post-traumatic period in patients with multiple blunt trauma (MBT). METHODS: The study included 52 patients admitted to the emergency department with MBT and 40 age- and sex-matched healthy control subjects. RESULTS: The overall MBT patient mortality was 32.7% (17/52). There was no significant association between age and mortality in MBT patients, but there was a negative correlation between mortality and RTS, and a positive correlation between mortality and ISS. TOS levels were significantly higher in nonsurvivors compared with survivors. There was no correlation between TAS or OSI and survival. ISS and RTS showed positive and negative correlations with TOS level, respectively, but neither was significantly related to TAS or OSI. CONCLUSIONS: These findings suggest that TOS, as an early oxidative stress biomarker, may be an objective alternative criterion to the ISS and RTS for managing patients with MBT during the early period following traumatic injury.en_US
dc.description.sponsorshipScientific Research Projects Committee of Harran University, Sanliurfa, Turkeyen_US
dc.description.sponsorshipThis study was supported by the Scientific Research Projects Committee of Harran University, Sanliurfa, Turkey.en_US
dc.identifier.doi10.1177/147323001204000117
dc.identifier.endpage173en_US
dc.identifier.issn0300-0605
dc.identifier.issue1en_US
dc.identifier.pmid22429356en_US
dc.identifier.scopus2-s2.0-84857874030en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage167en_US
dc.identifier.urihttps://doi.org/10.1177/147323001204000117
dc.identifier.urihttps://hdl.handle.net/20.500.14551/22561
dc.identifier.volume40en_US
dc.identifier.wosWOS:000302272300017en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherField House Publishing Llpen_US
dc.relation.ispartofJournal Of International Medical Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectMULTIPLE BLUNT TRAUMAen_US
dc.subjectTOTAL OXIDANT STATUSen_US
dc.subjectTOTAL ANTIOXIDANT STATUSen_US
dc.subjectOXIDATIVE STRESS INDEXen_US
dc.subjectINJURY SEVERITY SCOREen_US
dc.subjectMORTALITYen_US
dc.subjectCritically-Ill Patientsen_US
dc.subjectInjury Severity Scoreen_US
dc.subjectLipid-Peroxidationen_US
dc.subjectAntioxidant Statusen_US
dc.subjectAbdominal-Traumaen_US
dc.subjectBrain-Injuryen_US
dc.subjectHead-Injuryen_US
dc.subjectEpidemiologyen_US
dc.subjectPredictionen_US
dc.subjectCorrelateen_US
dc.titleRole of Oxidative Stress in the Clinical Outcome of Patients with Multiple Blunt Traumaen_US
dc.typeArticleen_US

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