Synthesis, spectral analysis, antimicrobial, cytotoxicity, and antioxidant studies of gold(III) complex of caffeine
Küçük Resim Yok
Tarih
2019
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Taylor & Francis Ltd
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
In the present study, the reactions involving caffeine (CA) and gold(III) were investigated. The synthesized complex was characterized by using mass, UV-visible, FTIR, H-1 and C-13 NMR, and TG-DTA analyses. From these analyses, it is predicted that the complex has the formula [Au(CA)(2)(Cl)(2)]Cl. In addition, antimicrobial, cytotoxicity, and antioxidant activities of the obtained complex were investigated. Investigation of antimicrobial properties demonstrated that the complex has important antibacterial and antifungal activities. The cytotoxic activity of the complex showed potent cytotoxicity against growth of human prostate (Du145), cervix (HeLa), colon (HT29), and breast (MCF7) cancer cells. Additionally, the complex showed significant antioxidant activity.
Açıklama
Anahtar Kelimeler
Gold(III), Spectral Analysis, Antimicrobial Activity, Cytotoxicity, Antioxidant Activity, N-Heterocyclic Carbenes, Natural-Products Synthesis, In-Vitro Cytotoxicity, Spectrophotometric Determination, Corresponding Gold(I), Biological-Activity, Solution Chemistry, Antitumor-Activity, Anticancer, Au(Iii)
Kaynak
Journal Of Coordination Chemistry
WoS Q Değeri
Q3
Scopus Q Değeri
Q3
Cilt
72
Sayı
12
