The clinical and pathological features of 133 colorectal cancer patients with brain metastasis: a multicenter retrospective analysis of the Gastrointestinal Tumors Working Committee of the Turkish Oncology Group (TOG)

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dc.authoridDepboylu Denizli, Bengu/0000-0002-9777-2917
dc.authoridGöksel, Gamze/0000-0002-7991-0036
dc.authoridbayoglu, ibrahim vedat/0000-0002-0481-1084
dc.authoridKaya, Vildan/0000-0001-9035-4977
dc.authoridÖksüzoğlu Çakmak, Ömür Berna/0000-0002-2756-8646
dc.authoridSaglam, Sezer/0000-0001-8954-5792
dc.authoridTanriverdi, Ozgur/0000-0002-0598-7284
dc.authorwosidDepboylu Denizli, Bengu/B-9156-2019
dc.authorwosidGöksel, Gamze/HHC-6548-2022
dc.authorwosidIbis, Kamuran/AAD-1939-2019
dc.authorwosidbayoglu, ibrahim vedat/HKN-8074-2023
dc.authorwosidKaya, Vildan/ABD-8956-2021
dc.authorwosidÖksüzoğlu Çakmak, Ömür Berna/HKN-6428-2023
dc.authorwosidulger, Sukran/HHS-1463-2022
dc.contributor.authorTanriverdi, Ozgur
dc.contributor.authorKaytan-Saglam, Esra
dc.contributor.authorUlger, Sukran
dc.contributor.authorBayoglu, Ibrahim Vedat
dc.contributor.authorTurker, Ibrahim
dc.contributor.authorOzturk-Topcu, Turkan
dc.contributor.authorCokmert, Suna
dc.date.accessioned2024-06-12T10:58:07Z
dc.date.available2024-06-12T10:58:07Z
dc.date.issued2014
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBrain metastasis in colorectal cancer is highly rare. In the present study, we aimed to determine the frequency of brain metastasis in colorectal cancer patients and to establish prognostic characteristics of colorectal cancer patients with brain metastasis. In this cross-sectional study, the medical files of colorectal cancer patients with brain metastases who were definitely diagnosed by histopathologically were retrospectively reviewed. Brain metastasis was detected in 2.7 % (n = 133) of 4,864 colorectal cancer patients. The majority of cases were male (53 %), older than 65 years (59 %), with rectum cancer (56 %), a poorly differentiated tumor (70 %); had adenocarcinoma histology (97 %), and metachronous metastasis (86 %); received chemotherapy at least once for metastatic disease before brain metastasis developed (72 %), had progression with lung metastasis before (51 %), and 26 % (n = 31) of patients with extracranial disease at time the diagnosis of brain metastasis had both lung and bone metastases. The mean follow-up duration was 51 months (range 5-92), and the mean survival was 25.8 months (95 % CI 20.4-29.3). Overall survival rates were 81 % in the first year, 42.3 % in the third year, and 15.7 % in the fifth year. In multiple variable analysis, the most important independent risk factor for overall survival was determined as the presence of lung metastasis (HR 1.43, 95 % CI 1.27-4.14; P = 0.012). Brain metastasis develops late in the period of colorectal cancer and prognosis in these patients is poor. However, early screening of brain metastases in patients with lung metastasis may improve survival outcomes with new treatment modalities.en_US
dc.identifier.doi10.1007/s12032-014-0152-z
dc.identifier.issn1357-0560
dc.identifier.issn1559-131X
dc.identifier.issue9en_US
dc.identifier.pmid25108599en_US
dc.identifier.scopus2-s2.0-84905298096en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1007/s12032-014-0152-z
dc.identifier.urihttps://hdl.handle.net/20.500.14551/19948
dc.identifier.volume31en_US
dc.identifier.wosWOS:000341835700025en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherHumana Press Incen_US
dc.relation.ispartofMedical Oncologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectColorectal Canceren_US
dc.subjectBrain Metastasisen_US
dc.subjectPrognosisen_US
dc.subjectPartitioning Analysis Rpaen_US
dc.subjectPrognostic-Factorsen_US
dc.subjectCarcinomaen_US
dc.subjectSurvivalen_US
dc.subjectRadiosurgeryen_US
dc.titleThe clinical and pathological features of 133 colorectal cancer patients with brain metastasis: a multicenter retrospective analysis of the Gastrointestinal Tumors Working Committee of the Turkish Oncology Group (TOG)en_US
dc.typeArticleen_US

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