Spleen tyrosine kinase inhibition in the treatment of autoimmune, allergic and autoinflammatory diseases
Küçük Resim Yok
Tarih
2010
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Bmc
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Spleen tyrosine kinase (Syk) is involved in the development of the adaptive immune system and has been recognized as being important in the function of additional cell types, including platelets, phagocytes, fibroblasts, and osteoclasts, and in the generation of the inflammasome. Preclinical studies presented compelling evidence that Syk inhibition may have therapeutic value in the treatment of rheumatoid arthritis and other forms of arthritis, systemic lupus erythematosus, autoimmune cytopenias, and allergic and autoinflammatory diseases. In addition, Syk inhibition may have a place in limiting tissue injury associated with organ transplant and revascularization procedures. Clinical trials have documented exciting success in the treatment of patients with rheumatoid arthritis, autoimmune cytopenias, and allergic rhinitis. While the extent and severity of side effects appear to be limited so far, larger studies will unravel the risk involved with the clinical benefit.
Açıklama
Anahtar Kelimeler
Receptor Gamma-Chain, B-Cell Development, Syk-Kinase, Rheumatoid-Arthritis, Activation, Inflammation, Phagocytosis, Challenge, Mechanism, Symptoms
Kaynak
Arthritis Research & Therapy
WoS Q Değeri
Q2
Scopus Q Değeri
Q1
Cilt
12
Sayı
6
