Effect of Lipoic Acid on Serum Paraoxonase-1 and Paraoxonase-3 Protein Levels and Activities in Diabetic Rats

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dc.contributor.authorOzgun, E.
dc.contributor.authorOzgun, G. S.
dc.contributor.authorGokmen, S. S.
dc.contributor.authorEskiocak, S.
dc.contributor.authorSut, N.
dc.contributor.authorAkinci, M.
dc.contributor.authorGoncu, E.
dc.date.accessioned2024-06-12T11:15:41Z
dc.date.available2024-06-12T11:15:41Z
dc.date.issued2019
dc.departmentTrakya Üniversitesien_US
dc.description.abstractThe aim of the present study was to investigate the effect of streptozotocin-induced diabetes mellitus and lipoic acid treatment on serum paraoxonase-1 and paraoxonase-3 protein levels and paraoxonase, arylesterase and lactonase activities. 36 rats were equally and randomly divided into 4 groups as control, lipoic acid, diabetes and diabetes + lipoic acid. To induce diabetes, a single dose of streptozotocin (40 mg/kg) was injected intraperitoneally to diabetes and diabetes + lipoic acid groups. Lipoic acid (10 mg/kg/day) was injected intraperitoneally for 14 days to lipoic acid and diabetes + lipoic acid groups. Serum PON1 and PON3 protein levels were measured bywestern blotting. Serum paraoxonase, arylesterase and lactonase activities were determined by the measuring initial rate of substrate (paraoxon, phenylacetate and dihydrocoumarin) hydrolysis. Streptozotocin-induced diabetes mellitus caused a significant decrease whereas lipoic acid treatment caused a significant increase in serum PON1 and PON3 protein levels and paraoxonase, arylesterase and lactonase activities. The increase percent of serum PON3 protein was higher than that of serum PON1 protein and the increase percent of serum lactonase activity was higher than that of serum paraoxonase and arylesterase activities in diabetes + lipoic acid group. We can report that, like PON1 protein, PON3 protein and actually its lactonase activity may also have a role as an antioxidant in diabetes mellitus and lipoic acid treatment may be useful for the prevention of the atherosclerotic complications of diabetes by increasing serum PON1 and PON3 protein levels and serum enzyme activities.en_US
dc.description.sponsorshipScientific Research Appropriation of Trakya University [TUBAP 2013/21]en_US
dc.description.sponsorshipThis study was supported by Scientific Research Appropriation of Trakya University (TUBAP 2013/21), Turkey.en_US
dc.identifier.doi10.1055/s-0042-101164
dc.identifier.endpage384en_US
dc.identifier.issn0947-7349
dc.identifier.issn1439-3646
dc.identifier.issue6en_US
dc.identifier.pmid26849669en_US
dc.identifier.scopus2-s2.0-84957615443en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage377en_US
dc.identifier.urihttps://doi.org/10.1055/s-0042-101164
dc.identifier.urihttps://hdl.handle.net/20.500.14551/24027
dc.identifier.volume127en_US
dc.identifier.wosWOS:000470715900005en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherJohann Ambrosius Barth Verlag Medizinverlage Heidelberg Gmbhen_US
dc.relation.ispartofExperimental And Clinical Endocrinology & Diabetesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectStreptozotocin-Induced Diabetes Mellitusen_US
dc.subjectLipoic Aciden_US
dc.subjectParaoxonase 1en_US
dc.subjectParaoxonase 3en_US
dc.subjectArylesteraseen_US
dc.subjectLactonaseen_US
dc.subjectLow-Density-Lipoproteinen_US
dc.subjectOxidative Stressen_US
dc.subjectAntioxidanten_US
dc.subjectHdlen_US
dc.subjectAtherosclerosisen_US
dc.subjectExpressionen_US
dc.subjectTaurineen_US
dc.subjectFamilyen_US
dc.subjectLactonaseen_US
dc.subjectTissuesen_US
dc.titleEffect of Lipoic Acid on Serum Paraoxonase-1 and Paraoxonase-3 Protein Levels and Activities in Diabetic Ratsen_US
dc.typeArticleen_US

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