Prognostic value of indocyanine green elimination assessed with LiMON in septic patients
Küçük Resim Yok
Tarih
2009
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
W B Saunders Co-Elsevier Inc
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Background: Sepsis is the most frequent infection with high mortality rates in intensive care units (ICUs), and the prediction of outcome is important in the decision-making process. Objective: To assess the value of the Acute Physiology and Chronic Health Evaluation II (APACHE II) and indocyanin green (ICG) plasma disappearance rate (ICG-PDR) in septic patients. Design: Retrospective analysis. Measurements and Results: We analyzed 40 septic patients (17 female and 23 male; age range, 20-89 years) who were treated in our ICU. The ICG-PDR measurement and APACHE II score measurement were made within 24 hours after admission to the ICU. Indocyanine green elimination tests were conducted concurrently using the noninvasive liver function monitoring system (LiMON, Pulsion Medical Systems, Munich, Germany). A dose of 0.3 mg/kg ICG was given through a cubital fossa vein as a bolus. Results: Statistical analysis showed that ICG-PDR was significantly tower in nonsurvivors (n = 18) than in survivors (n = 22) (mean, 12.1% +/- 7.6%/min; median, 9%/min, vs mean, 21.2% +/- 10.1%/min; median, 20%/min, respectively [P = .004]). The area under the curve as a measure of accuracy was 0.765 for ICG-PDR and 0.692 for APACHE II. Mortality was 80% in patients with ICG-PDR below 8% per minute, and survival was approximately 89% in patients with ICG-PDR above 24% per minute. Conclusion: The results suggest that ICG-PDR, assessed with a user-friendly noninvasive bedside LiMON device, is a good predictor of survival in septic patients. Sensitivity and specificity of the noninvasive measurement of ICG-PDR on ICU admission was comparable to that obtained by APACHE II scores. (C) 2009 Elsevier Inc. All rights reserved.
Açıklama
8th International Conference on Complexity in Acute Illness -- AUG 28-30, 2009 -- Palo Alto, CA
Anahtar Kelimeler
Indocyanine Green, Plasma Disappearance Rate, Acute Physiology And Chronic Health Evaluation, Prognostic Factor, Sepsis, Plasma Disappearance Rate, Liver-Transplantation, Clearance, Sepsis, Perfusion, Apache, Shock
Kaynak
Journal Of Critical Care
WoS Q Değeri
Q3
Scopus Q Değeri
Q1
Cilt
24
Sayı
3
