Effects of Bone Marrow and Adipose-Derived Mesenchymal Stem Cells on microRNA Expressions in Acute Alkaline Corneal Burn

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dc.authoridyilmaz, şakir necat/0000-0003-1759-3052
dc.authoridBayrak, Gülsen/0000-0002-1397-7203
dc.authoridYilmaz, Nejat/0000-0003-0637-3687
dc.authoridÖzer, Ömer/0000-0003-0329-0931;
dc.authorwosidÖzer, Ömer/AAO-8455-2021
dc.authorwosidyilmaz, şakir necat/AAA-5270-2022
dc.authorwosidBayrak, Gülsen/HJP-9011-2023
dc.authorwosidYilmaz, Nejat/JMB-6519-2023
dc.authorwosidÖzer, Ömer/ABE-0248-2022
dc.authorwosidAyaz, Lokman/K-6716-2013
dc.contributor.authorDinc, Erdem
dc.contributor.authorAyaz, Lokman
dc.contributor.authorKurt, A. Hakan
dc.contributor.authorDursun, Ozer
dc.contributor.authorYilmaz, Gulsen
dc.contributor.authorVatansever, Mustafa
dc.contributor.authorOzer, Omer
dc.date.accessioned2024-06-12T10:51:11Z
dc.date.available2024-06-12T10:51:11Z
dc.date.issued2021
dc.departmentTrakya Üniversitesien_US
dc.description.abstractPurpose: The aim of this study was to investigate the microRNA (miRNA) expressions of the corneal tissue after an alkaline burn and to compare the efficiency of adipose- and bone marrow-derived mesenchymal stem cells (MSCs) on expressions. Methods: Thirty-two rats were divided into 4 groups. No intervention was made in the control group. A chemical burn was created by applying 4 mu L NaOH soaked in 6 mm filter paper to the right eye of each animal in the other groups. Whereas only subconjunctival 0.1 mL phosphate-buffered saline (PBS) was injected to in the group 1, 2 x 10(6) adipose- or bone marrow-derived MSC in 0.1 mL PBS was injected subconjunctivally to the animals in the remaining groups (groups 2 and 3, respectively). Tissue samples were collected for miRNA analysis on the third day after the burn. Results: When group 1 was compared with the control group, the expression of 3 of 93 miRNAs increased significantly, whereas the expression of 50 miRNAs decreased significantly. Significant changes in miRNA expressions were observed when group 1 was compared with groups 2 and 3. Although a significant change was observed in the expression of 6 miRNAs in the adipose-derived MSC group, it was found that the expression of 65 miRNAs significantly changed in the bone marrow-derived MSC group. Conclusion: This study shows that there are significant changes in some miRNA expressions after corneal alkaline burn and these changes can be reversed with the subconjunctival injection of MSCs.en_US
dc.identifier.doi10.1089/jop.2020.0107
dc.identifier.endpage208en_US
dc.identifier.issn1080-7683
dc.identifier.issn1557-7732
dc.identifier.issue4en_US
dc.identifier.pmid33481657en_US
dc.identifier.scopus2-s2.0-85105719007en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage200en_US
dc.identifier.urihttps://doi.org/10.1089/jop.2020.0107
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18277
dc.identifier.volume37en_US
dc.identifier.wosWOS:000648085500003en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMary Ann Liebert, Incen_US
dc.relation.ispartofJournal Of Ocular Pharmacology And Therapeuticsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAlkaline Corneal Burnen_US
dc.subjectMesenchymal Stem Cellen_US
dc.subjectMirnaen_US
dc.titleEffects of Bone Marrow and Adipose-Derived Mesenchymal Stem Cells on microRNA Expressions in Acute Alkaline Corneal Burnen_US
dc.typeArticleen_US

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