MEFV Gene Exon 2 and Exon 10 Gene Region Mutations of Familial Mediterranean Fever Patients in Trakya Population

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dc.authoridGürkan, Hakan/0000-0002-8967-6124
dc.authorwosidGürkan, Hakan/AAF-2866-2020
dc.contributor.authorGurkan, Hakan
dc.contributor.authorOzkayin, Emine Nese
dc.contributor.authorTabakcioglu, Kiymet
dc.contributor.authorAlgunes, Cetin
dc.date.accessioned2024-06-12T11:01:46Z
dc.date.available2024-06-12T11:01:46Z
dc.date.issued2010
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjectives: The objective of the study is to explore the MEFV gene exon 2 and exon 10 gene region mutations which take place in etiopathogenesis of Familial Mediterranean Fever in the Thrace population with the DNA sequence analysis method and to compare the results with the other studies. Patients and Methods: The study included patients with Familial Mediterranean Fever who have no relative relationship, have the same linguistic characteristic and live in the Thrace region for at least three generations (34 females, 34 males). MEFV gene exon 2 and exon 10 gene regions multiplied with PCR and their nucleotids were determined with the DNA sequence analysis method. Results: G442C, T306C, A414G, C495A, G605A SNPs were found in MEFV gene exon 2 gene region and G20400, A2080G, 02082A, A2084G, T2177C, G2282A SNPs were found in MEFV gene exon 10 gene region in the Thrace population. Conclusion: The T306C, A414G, C495A, G605 single-nucleotide polymorphisms in MEFV gene exon 2 gene region and the mutations in exon 10 gene region are not compatible in terms of their frequencies with the results of the other studies.en_US
dc.identifier.endpage43en_US
dc.identifier.issn1301-3149
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-77950483594en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage37en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14551/21014
dc.identifier.volume27en_US
dc.identifier.wosWOS:000277173500008en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isotren_US
dc.publisherAves Yayincilik, Ibrahim Karaen_US
dc.relation.ispartofTrakya Universitesi Tip Fakultesi Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectFamilial Mediterranean Feveren_US
dc.subjectDNA Sequencingen_US
dc.subjectMutationsen_US
dc.subjectSingle-Nucleotide Polymorphismsen_US
dc.subjectTurkeyen_US
dc.subjectFmfen_US
dc.subjectAssociationen_US
dc.subjectGenotypeen_US
dc.titleMEFV Gene Exon 2 and Exon 10 Gene Region Mutations of Familial Mediterranean Fever Patients in Trakya Populationen_US
dc.typeArticleen_US

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