Comparison of clinicopathological features in patients with noninvasive follicular thyroid neoplasm with papillary-like nuclear features and follicular variant papillary thyroid cancer

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dc.authoridCelik, Mehmet/0000-0001-7364-370X
dc.authoridAytürk Salt, Semra/0000-0002-1560-3459
dc.authoridyılmaz bülbül, buket/0000-0003-2651-0036
dc.authorwosidCelik, Mehmet/AAA-8773-2021
dc.authorwosidAytürk Salt, Semra/U-4265-2017
dc.authorwosidyılmaz bülbül, buket/JVZ-4676-2024
dc.contributor.authorCelik, Mehmet
dc.contributor.authorBulbul, Buket Y.
dc.contributor.authorCan, Nuray
dc.contributor.authorAyturk, Semra
dc.contributor.authorTastekin, Ebru
dc.contributor.authorSezer, Atakan
dc.contributor.authorUstun, Funda
dc.date.accessioned2024-06-12T11:02:05Z
dc.date.available2024-06-12T11:02:05Z
dc.date.issued2020
dc.departmentTrakya Üniversitesien_US
dc.description.abstractINTRODUCTION Noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) is a newly defined entity accepted as a tumor precursor. OBJECTIVE We aimed to examine the features of patients diagnosed with follicular variant papillary thyroid carcinoma (FVPTC), which are classified as NIFTP in the recent classification. This study compares clinical, radiological, histopathological, and molecular features of NIFTP and FVPTC. PATIENTS AND METHODS A total of 247 patients with FVPTC were retrospectively examined and pathology specimens were reviewed. RESULTS Patients were divided into 2 groups (NIFTP group: 107 patients; FVPTC group: 140 patients). There was a difference in terms of the percentage of pathologic nodules with irregular borders detected on preoperative neck ultrasonography (NIFTP group: 6.5%, FVPTC group: 15.7%; P = 0.02). Central lymph node dissection specimens of 50 patients in the NIFTP group were normal, while 4 of 70 patients (5.7%) in the FVPTC group had lymph node metastasis (P = 0.14). In addition, multivariable analysis (binary logistic regression) showed that FVPTC was positively associated only with irregular borders and extrathyroidal extensions (P = 0.02 and P <0.001, respectively). CONCLUSIONS We suggest that patients diagnosed with NIFTP according to the new classification are considered low risk, and margin characteristics of the nodule detected on preoperative ultrasonography may be helpful in the differential diagnosis.en_US
dc.identifier.doi10.20452/pamw.15120
dc.identifier.endpage105en_US
dc.identifier.issn0032-3772
dc.identifier.issn1897-9483
dc.identifier.issue2en_US
dc.identifier.pmid31895349en_US
dc.identifier.scopus2-s2.0-85080837086en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage100en_US
dc.identifier.urihttps://doi.org/10.20452/pamw.15120
dc.identifier.urihttps://hdl.handle.net/20.500.14551/21142
dc.identifier.volume130en_US
dc.identifier.wosWOS:000518196600005en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMedycyna Praktyczna Sp K Sp Zooen_US
dc.relation.ispartofPolish Archives Of Internal Medicine-Polskie Archiwum Medycyny Wewnetrznejen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectFollicular Variant Of Papillary Thyroid Carcinomaen_US
dc.subjectNoninvasive Follicular Thyroid Neoplasm With Papillary-Like Nuclear Featuresen_US
dc.subjectUltrasonographyen_US
dc.subjectClinical-Experienceen_US
dc.subjectRisk Stratificationen_US
dc.subjectBraf V600een_US
dc.subjectCarcinomaen_US
dc.subjectDiagnosisen_US
dc.subjectNodulesen_US
dc.subjectAssociationen_US
dc.subjectImpacten_US
dc.subjectTumorsen_US
dc.titleComparison of clinicopathological features in patients with noninvasive follicular thyroid neoplasm with papillary-like nuclear features and follicular variant papillary thyroid canceren_US
dc.typeArticleen_US

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