Significance of the interval between first and second transurethral resection on recurrence and progression rates in patients with high-risk non-muscle-invasive bladder cancer treated with maintenance intravesical Bacillus Calmette-Guerin

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dc.authoridAslan, Güven/0000-0003-3715-1761
dc.authoridBozlu, Murat/0000-0002-8624-0149
dc.authoridGokce, Mehmet/0000-0002-2370-548X
dc.authorwosidTürkeri, Levent N./W-9283-2018
dc.authorwosidAslan, Güven/JVO-5099-2024
dc.authorwosidYildirim, Asif/N-5388-2019
dc.authorwosidCan, Cavit/ABH-7223-2020
dc.authorwosidBozlu, Murat/O-5281-2017
dc.contributor.authorBaltaci, Sumer
dc.contributor.authorBozlu, Murat
dc.contributor.authorYildirim, Asif
dc.contributor.authorGokce, Mehmet Ilker
dc.contributor.authorTinay, Ilker
dc.contributor.authorAslan, Guven
dc.contributor.authorCan, Cavit
dc.date.accessioned2024-06-12T11:09:18Z
dc.date.available2024-06-12T11:09:18Z
dc.date.issued2015
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjectives To evaluate the effect of the interval between the initial and second transurethral resection (TUR) on the outcome of patients with high-risk non-muscle-invasive bladder cancer (NMIBC) treated with maintenance intravesical Bacillus Calmette-Guerin (BCG) therapy. Patients and Methods We reviewed the data of patients from 10 centres treated for high-risk NMIBC between 2005 and 2012. Patients without a diagnosis of muscle-invasive cancer on second TUR performed <= 90 days after a complete first TUR, and received at least 1 year of maintenance BCG were included in this study. The interval between first and second TUR in addition to other parameters were recorded. Multivariate logistic regression analysis was used to identify predictors of recurrence and progression. Results In all, 242 patients were included. The mean (SD, range) follow-up was 29.4 (22.2, 12-96) months. The 3-year recurrence-and progression-free survival rates of patients who underwent second TUR between 14 and 42 days and 43-90 days were 73.6% vs 46.2% (P < 0.001) and 89.1% vs 79.1% (P = 0.006), respectively. On multivariate analysis, the interval to second TUR was found to be a predictor of both recurrence [odds ratio (OR) 3.598, 95% confidence interval (CI) 1.885-8.137; P = 0.001] and progression (OR 2.144, 95% CI 1.447-5.137; P = 0.003). Conclusions The interval between first and second TUR should be <= 42 days in order to attain lower recurrence and progression rates. To our knowledge, this is the first study demonstrating the effect of the interval between first and second TUR on patient outcomes.en_US
dc.identifier.doi10.1111/bju.13102
dc.identifier.endpage726en_US
dc.identifier.issn1464-4096
dc.identifier.issn1464-410X
dc.identifier.issue5en_US
dc.identifier.pmid25715815en_US
dc.identifier.scopus2-s2.0-84943523979en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage721en_US
dc.identifier.urihttps://doi.org/10.1111/bju.13102
dc.identifier.urihttps://hdl.handle.net/20.500.14551/22767
dc.identifier.volume116en_US
dc.identifier.wosWOS:000362574800013en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWiley-Blackwellen_US
dc.relation.ispartofBju Internationalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectNon-Muscle-Invasive Bladder Canceren_US
dc.subjectSecond Transurethral Resectionen_US
dc.subjectBacillus Calmette-Guerinen_US
dc.subjectMaintenance Bacillus Calmette-Guerinen_US
dc.subjectUrothelial Carcinomaen_US
dc.subjectMitomycin-Cen_US
dc.subjectMetaanalysisen_US
dc.subjectTumoren_US
dc.titleSignificance of the interval between first and second transurethral resection on recurrence and progression rates in patients with high-risk non-muscle-invasive bladder cancer treated with maintenance intravesical Bacillus Calmette-Guerinen_US
dc.typeArticleen_US

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