Regenerative hyperplasia of follicular epithelium in chronic lymphocytic thyroiditis

Basit Öğe Kaydı
dc.authoridPuyan, Fulya/0000-0001-5853-0109
dc.authoridOz Puyan, Fulya/0000-0001-5853-0109
dc.authorwosidPuyan, Fulya/V-7074-2019
dc.authorwosidOz Puyan, Fulya/A-7077-2018
dc.contributor.authorDoganay, L
dc.contributor.authorPuyan, FO
dc.contributor.authorOz, F
dc.contributor.authorErgul, Z
dc.contributor.authorBilgi, S
dc.contributor.authorEkuklu, G
dc.date.accessioned2024-06-12T11:07:56Z
dc.date.available2024-06-12T11:07:56Z
dc.date.issued2005
dc.departmentTrakya Üniversitesien_US
dc.description.abstractThe thyroid gland is an endocrine organ composed of stable cells. It is well known that regenerative capacity of the thyroid tissue is minimal. Various degrees of morphologic alterations do occur in chronic lymphocytic thyroiditis (CLT), including Hashimoto's thyroiditis. Eighty-five CLT cases were analyzed for these morphologic alterations. Small, irregular, atrophic or hyperplastic thyroid follicles were seen adjacent to the lymphocytic infiltration. There was nuclear enlargement, loss of nuclear polarity in thyrocytes and intrafollicular thyrocyte proliferation in these follicles. We thought that the morphologic alterations in involved follicles could be due to regenerative hyperplasia with increased proliferative activity and basement membrane abnormalities. To examine this hypothesis we investigated Ki-67 and laminin immunoreactivity in the involved follicles adjacent to lymphocytic infiltration areas. The uninvolved follicles were used as controls. Immunopositivity of Ki-67 in involved follicles was significantly higher than that in uninvolved follicles (2.97% +/- 2.16 versus 0.83% +/- 1.63, P < 0.001). Laminin immunostaining indicated the destruction or irregular distribution of basement membrane in involved follicles. We conclude that the increased cell proliferation activity and basement membrane abnormalities in the follicles with morphologic changes adjacent to CLT occur in conjunction with regenerative hyperplasia.en_US
dc.identifier.endpage357en_US
dc.identifier.issn1062-3345
dc.identifier.issue4en_US
dc.identifier.pmid16280665en_US
dc.identifier.scopus2-s2.0-28144443430en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage353en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14551/22243
dc.identifier.volume13en_US
dc.identifier.wosWOS:000233572700009en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofApplied Immunohistochemistry & Molecular Morphologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectLymphocytic Thyroiditisen_US
dc.subjectRegenerative Hyperplasiaen_US
dc.subjectKi-67en_US
dc.subjectBasement Membraneen_US
dc.subjectLamininen_US
dc.subjectHashimotos-Thyroiditisen_US
dc.subjectGraves-Diseaseen_US
dc.subjectExpressionen_US
dc.subjectCarcinomaen_US
dc.subjectP27(Kip1)en_US
dc.subjectProteinen_US
dc.subjectTumorsen_US
dc.titleRegenerative hyperplasia of follicular epithelium in chronic lymphocytic thyroiditisen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu